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Fcrlb Gene Detail
Summary
  • Symbol
    Fcrlb
  • Name
    Fc receptor-like B
  • Synonyms
    FcRL2, Fcry, FREB-2, FREB2, mFCRL2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3576487
    NCBI Gene: 435653
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:170734842-170740510 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 77.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    329 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3576487
 protein coding gene Chr1:170734284-170741396 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016736
 protein coding gene Chr1:176656832-176664109 (-)
A/J MGP_AJ_G0016716
 protein coding gene Chr1:169457777-169463428 (-)
AKR/J MGP_AKRJ_G0016682
 protein coding gene Chr1:174527731-174535256 (-)
BALB/cJ MGP_BALBcJ_G0016677
 protein coding gene Chr1:169913685-169919361 (-)
C3H/HeJ MGP_C3HHeJ_G0016500
 protein coding gene Chr1:174783821-174790400 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017138
 protein coding gene Chr1:182503405-182511432 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014847
 protein coding gene Chr1:161169746-161174906 (-)
CAST/EiJ MGP_CASTEiJ_G0016081
 protein coding gene Chr1:174417209-174422957 (-)
CBA/J MGP_CBAJ_G0016475
 protein coding gene Chr1:188992146-188998021 (-)
DBA/2J MGP_DBA2J_G0016582
 protein coding gene Chr1:168295735-168301398 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0016653
 protein coding gene Chr1:177777326-177783011 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016605
 protein coding gene Chr1:196305357-196312016 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017175
 protein coding gene Chr1:174429054-174435879 (-)
PWK/PhJ MGP_PWKPhJ_G0015867
 protein coding gene Chr1:167549338-167555180 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015651
 protein coding gene Chr1:173180817-173186536 (-)
WSB/EiJ MGP_WSBEiJ_G0016143
 protein coding gene Chr1:174550145-174555838 (-)



Homology
more
  • Human Ortholog
    FCRLB, Fc receptor like B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCRLB, Fc receptor like B
  • Synonyms
    FCRL2, FCRLM2, FCRLY, FcRY, FREB-2, FREB2
  • Links
    NCBI Gene ID: 127943
    neXtProt AC: NX_Q6BAA4
    UniProt: Q6BAA4

  • Chr Location
    1q23.3; chr1:161721544-161728143 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit an enhanced antibody response to a T-dependent antigen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    2
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070524 Ensembl Gene Model | MGI Sequence Detail 5669 C57BL/6J ±  kb
transcript ENSMUST00000094337 Ensembl | MGI Sequence Detail 1284 Not Applicable  
polypeptide ENSMUSP00000091895 Ensembl | MGI Sequence Detail 427 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:103474 Masuda K, et al., FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. Gene. 2005 Dec 19;363:32-40
  • Latest
    J:267727 Chessum L, et al., Helios is a key transcriptional regulator of outer hair cell maturation. Nature. 2018 Nov;563(7733):696-700
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory