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Pram1 Gene Detail
Summary
  • Symbol
    Pram1
  • Name
    PML-RAR alpha-regulated adaptor molecule 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3576625
    NCBI Gene: 378460
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:33857030-33864680 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3576625
 protein coding gene Chr17:33857030-33864680 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023532
 protein coding gene Chr17:33553047-33560697 (+)
A/J MGP_AJ_G0023491
 protein coding gene Chr17:32400833-32408492 (+)
AKR/J MGP_AKRJ_G0023457
 protein coding gene Chr17:32783685-32791845 (+)
BALB/cJ MGP_BALBcJ_G0023495
 protein coding gene Chr17:32553343-32560985 (+)
C3H/HeJ MGP_C3HHeJ_G0023258
 protein coding gene Chr17:33129690-33137314 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023939
 protein coding gene Chr17:34787379-34795029 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021412
 protein coding gene Chr17:29929393-29936685 (+)
CAST/EiJ MGP_CASTEiJ_G0022760
 protein coding gene Chr17:33240843-33249721 (+)
CBA/J MGP_CBAJ_G0023234
 protein coding gene Chr17:36200062-36207687 (+)
DBA/2J MGP_DBA2J_G0023363
 protein coding gene Chr17:31793817-31801495 (+)
FVB/NJ MGP_FVBNJ_G0023332
 protein coding gene Chr17:31646157-31653806 (+)
LP/J MGP_LPJ_G0023441
 protein coding gene Chr17:33841612-33849262 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023352
 protein coding gene Chr17:35256366-35264015 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023979
 protein coding gene Chr17:33106251-33113890 (+)
PWK/PhJ MGP_PWKPhJ_G0022508
 protein coding gene Chr17:30685134-30692785 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022324
 protein coding gene Chr17:31076612-31084266 (+)
WSB/EiJ MGP_WSBEiJ_G0022819
 protein coding gene Chr17:33152589-33160233 (+)



Homology
more
  • Human Ortholog
    PRAM1, PML-RARA regulated adaptor molecule 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRAM1, PML-RARA regulated adaptor molecule 1
  • Synonyms
    PML-RAR, PRAM-1
  • Links
    NCBI Gene ID: 84106
    neXtProt AC: NX_Q96QH2
    UniProt: Q96QH2

  • Chr Location
    19p13.2; chr19:8490056-8502640 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have neutrophils that exhibit decreased adhesion-dependent reactive oxygen intermediate production and degranulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    6
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 378460 NCBI Gene Model | MGI Sequence Detail 7651 C57BL/6J ±  kb
    transcript NM_001002842 RefSeq | MGI Sequence Detail 2290 C57BL/6  
    polypeptide Q6BCL1 UniProt | EBI | MGI Sequence Detail 675 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 1
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:95253 Clemens RA, et al., PRAM-1 is required for optimal integrin-dependent neutrophil function. Mol Cell Biol. 2004 Dec;24(24):10923-32
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory