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Rhox8 Gene Detail
Summary
  • Symbol
    Rhox8
  • Name
    reproductive homeobox 8
  • Synonyms
    Tox
  • Feature Type
    protein coding gene
  • IDs
    MGI:3579898
    NCBI Gene: 434768
  • Member of
    Rhox cluster
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:36963655-36967821 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 22.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3579898
 protein coding gene ChrX:36963655-36979643 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035653
 protein coding gene ChrX:32805593-32809588 (-)
A/J MGP_AJ_G0035639
 protein coding gene ChrX:32873507-32877556 (-)
AKR/J MGP_AKRJ_G0035558
 protein coding gene ChrX:33608627-33613325 (-)
BALB/cJ MGP_BALBcJ_G0035622
 protein coding gene ChrX:32557274-32561362 (-)
C3H/HeJ MGP_C3HHeJ_G0035327
 protein coding gene ChrX:33134978-33139398 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036152
 protein coding gene ChrX:33517727-33521764 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0035302
 protein coding gene ChrX:34353648-34357736 (-)
DBA/2J MGP_DBA2J_G0035456
 protein coding gene ChrX:32709694-32713770 (-)
FVB/NJ MGP_FVBNJ_G0035405
 protein coding gene ChrX:32431983-32435855 (-)
LP/J MGP_LPJ_G0035543
 protein coding gene ChrX:33185790-33189896 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035442
 protein coding gene ChrX:34729254-34733144 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036173
 protein coding gene ChrX:32831336-32835454 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0034165
 protein coding gene ChrX:21630037-21636215 (+)
WSB/EiJ MGP_WSBEiJ_G0034765
 protein coding gene ChrX:32531481-32535389 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    3
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064137 Ensembl Gene Model | MGI Sequence Detail 4167 C57BL/6J ±  kb
transcript ENSMUST00000071885 Ensembl | MGI Sequence Detail 1204 Not Applicable  
polypeptide ENSMUSP00000071782 Ensembl | MGI Sequence Detail 320 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001356 Homeobox domain
    IPR009057 Homeobox-like domain superfamily
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:88542 Kang YL, et al., A novel PEPP homeobox gene, TOX, is highly glutamic acid rich and specifically expressed in murine testis and ovary. Biol Reprod. 2004 Mar;70(3):828-36
  • Latest
    J:342643 Oh Y, et al., Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice. Biol Reprod. 2023 Oct 13;109(4):520-532
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory