Agap2 MGI Mouse Gene Detail - MGI:3580016 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Symbol

Agap2
Name

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms

Centg1, PIKE-A, PIKE-L

Feature Type

protein coding gene
IDs

MGI:3580016
NCBI Gene: 216439
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr10:126911154-126929039 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 74.50 cM
Mapping Data

1 experiment

SNPs within 2kb

385 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3580016	protein coding gene	Chr10:126911153-126929039 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017806	protein coding gene	Chr10:130656433-130674090 (+)
A/J	MGP_AJ_G0017781	protein coding gene	Chr10:125423078-125437294 (+)
AKR/J	MGP_AKRJ_G0017744	protein coding gene	Chr10:129137880-129152742 (+)
BALB/cJ	MGP_BALBcJ_G0017745	protein coding gene	Chr10:125833021-125847620 (+)
C3H/HeJ	MGP_C3HHeJ_G0017569	protein coding gene	Chr10:129272424-129286651 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018200	protein coding gene	Chr10:135084311-135100648 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015880	protein coding gene	Chr10:119447892-119462068 (+)
CAST/EiJ	MGP_CASTEiJ_G0017129	protein coding gene	Chr10:129924242-129938187 (+)
CBA/J	MGP_CBAJ_G0017538	protein coding gene	Chr10:140505035-140521981 (+)
DBA/2J	MGP_DBA2J_G0017644	protein coding gene	Chr10:124512859-124527686 (+)
FVB/NJ	MGP_FVBNJ_G0017639	protein coding gene	Chr10:123462153-123477414 (+)
LP/J	MGP_LPJ_G0017718	protein coding gene	Chr10:131225630-131244385 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017667	protein coding gene	Chr10:143247221-143262617 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018240	protein coding gene	Chr10:129196857-129211008 (+)
PWK/PhJ	MGP_PWKPhJ_G0016914	protein coding gene	Chr10:124703203-124717899 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016706	protein coding gene	Chr10:128216576-128232975 (+)
WSB/EiJ	MGP_WSBEiJ_G0017190	protein coding gene	Chr10:129419057-129433323 (+)

Human Ortholog

AGAP2, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AGAP2, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms

CENTG1, GGAP2, PIKE
Links

HGNC:16921

NCBI Gene ID: 116986

neXtProt AC: NX_Q99490

UniProt: Q99490
Chr Location

12q14.1; chr12:57723761-57742161 (-) GRCh38

MGI Vertebrate Homology

Agap2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AGAP2
Gene Tree

Agap2

Diseases

1 with human AGAP2 associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

18 phenotypes from 2 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired lactation due to abnormal mammary gland growth during lactation, failure of insulin-suppressed gluconeogenesis, and hyperglycemia.

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All GO Annotations

69
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase agap2

ZFIN agap2

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All Sequences

47
RefSeq

14
UniProt

2
CCDS

CCDS24228.1, CCDS88097.1

Ensembl

ENSMUSG00000025422 (Evidence)
NCBI Gene

216439

			Length	Strain/Species	Flank
genomic	216439	NCBI Gene Model \| MGI Sequence Detail	17886	C57BL/6J	± kb
transcript	NM_001033263	RefSeq \| MGI Sequence Detail	5645	C57BL/6
polypeptide	Q3UHD9	UniProt \| EBI \| MGI Sequence Detail	1186	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003816 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR038508 ArfGAP domain superfamily

IPR037278 ARFGAP/RecO-like zinc finger

IPR051282 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein

IPR001164 Arf GTPase activating protein

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase
GlyGen

Q3UHD9 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 8

cDNA 8

Microarray probesets 3

Summaries

All 41

Gene Ontology 9

Phenotypes 14
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Agap2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96119	Chr10:126911134-126911194 (+)	10 bp
Tssr96120	Chr10:126911198-126911267 (+)	79 bp
Tssr96121	Chr10:126914755-126914787 (+)	3,617 bp
Tssr96122	Chr10:126914791-126914815 (+)	3,649 bp
Tssr96123	Chr10:126914833-126914834 (+)	3,680 bp
Tssr96124	Chr10:126914857-126914860 (+)	3,705 bp
Tssr96125	Chr10:126914875-126914893 (+)	3,730 bp
Tssr96126	Chr10:126914903-126914904 (+)	3,750 bp
Tssr96127	Chr10:126914909-126914938 (+)	3,770 bp
Tssr96128	Chr10:126914984-126914996 (+)	3,836 bp
Tssr96129	Chr10:126915028-126915039 (+)	3,880 bp
Tssr96130	Chr10:126920450-126920455 (+)	9,299 bp
Tssr96131	Chr10:126920525-126920542 (+)	9,380 bp
Tssr96132	Chr10:126920595-126920615 (+)	9,451 bp
Tssr96133	Chr10:126922765-126922775 (+)	11,616 bp
Tssr96134	Chr10:126928536-126928557 (+)	17,393 bp
Tssr96135	Chr10:126928906-126928910 (+)	17,754 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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