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Dgkk Gene Detail
Summary
  • Symbol
    Dgkk
  • Name
    diacylglycerol kinase kappa
  • Feature Type
    protein coding gene
  • IDs
    MGI:3580254
    NCBI Gene: 331374
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:6691103-6814602 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2181 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3580254
 protein coding gene ChrX:6690410-6814602 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035506
 protein coding gene ChrX:1407187-1526815 (+)
A/J MGP_AJ_G0035484
 protein coding gene ChrX:1387542-1509899 (+)
AKR/J MGP_AKRJ_G0035417
 protein coding gene ChrX:1447285-1579467 (+)
BALB/cJ MGP_BALBcJ_G0035480
 protein coding gene ChrX:1412553-1533981 (+)
C3H/HeJ MGP_C3HHeJ_G0035188
 protein coding gene ChrX:1440282-1561792 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036004
 protein coding gene ChrX:1469383-1602845 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032879
 protein coding gene ChrX:946207-1083138 (+)
CAST/EiJ MGP_CASTEiJ_G0034488
 protein coding gene ChrX:1335343-1462849 (+)
CBA/J MGP_CBAJ_G0035158
 protein coding gene ChrX:1560487-1689260 (+)
DBA/2J MGP_DBA2J_G0035315
 protein coding gene ChrX:1426705-1546941 (+)
FVB/NJ MGP_FVBNJ_G0035262
 protein coding gene ChrX:1374074-1508820 (+)
LP/J MGP_LPJ_G0035392
 protein coding gene ChrX:1415562-1537356 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035301
 protein coding gene ChrX:1525470-1658877 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036022
 protein coding gene ChrX:1407312-1531161 (+)
PWK/PhJ MGP_PWKPhJ_G0034190
 protein coding gene ChrX:1333403-1459419 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034027
 protein coding gene ChrX:1339603-1467925 (+)
WSB/EiJ MGP_WSBEiJ_G0034611
 protein coding gene ChrX:1402983-1529284 (+)



Homology
more
  • Human Ortholog
    DGKK, diacylglycerol kinase kappa
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGKK, diacylglycerol kinase kappa
  • Links
    NCBI Gene ID: 139189
    neXtProt AC: NX_Q5KSL6
    UniProt: Q5KSL6

  • Chr Location
    Xp11.22; chrX:50365409-50470825 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    22
  • cDNA Data
    5
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 331374 NCBI Gene Model | MGI Sequence Detail 123500 C57BL/6J ±  kb
    transcript NM_177914 RefSeq | MGI Sequence Detail 7172 C57BL/6  
    polypeptide NP_808582 RefSeq | MGI Sequence Detail 1118 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
      2.7.1.107
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR037607 Diacylglycerol kinase
      IPR000756 Diacylglycerol kinase, accessory domain
      IPR001206 Diacylglycerol kinase, catalytic domain
      IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
      IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 5
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 23
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 3
    • Earliest
      J:115297 Crotty T, et al., Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15485-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory