Gsdmc3 MGI Mouse Gene Detail - MGI:3580656

Symbol

Gsdmc3
Name

gasdermin C3
Synonyms

9930109F21Rik

Feature Type

protein coding gene
IDs

MGI:3580656
NCBI Gene: 270328
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr15:63729573-63750407 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 27.99 cM
Mapping Data

1 experiment

SNPs within 2kb

295 from dbSNP Build 142
Strain Annotations

9

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3580656	protein coding gene	Chr15:63729454-63750428 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021893	protein coding gene	Chr15:63305485-63332088 (-)
A/J	MGP_AJ_G0021852	protein coding gene	Chr15:60836871-60915384 (-)
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0021859	protein coding gene	Chr15:61022263-61042460 (-)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0022298	protein coding gene	Chr15:65603179-65798341 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019838	protein coding gene	Chr15:57735608-57762532 (-)
CAST/EiJ	MGP_CASTEiJ_G0021149	protein coding gene	Chr15:63240781-63296870 (-)
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0022321	protein coding gene	Chr15:62918776-62946337 (-)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0020735	protein coding gene	Chr15:62826355-62841467 (-)
WSB/EiJ	no annotation

Human Ortholog

GSDMC, gasdermin C

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GSDMC, gasdermin C
Synonyms

MLZE
Links

HGNC:7151

NCBI Gene ID: 56169

neXtProt AC: NX_Q9BYG8

UniProt: Q9BYG8
Chr Location

8q24.21; chr8:129705435-129786624 (-) GRCh38

MGI Vertebrate Homology

Gsdmc3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GSDMC
Gene Tree

Gsdmc3

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References

1 with disease annotations

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Phenotype Summary

24 phenotype references

All Mutations and Alleles

10
Chemically induced (other)

3
Radiation induced

2
Transposon induced

5
Genomic Mutations

10 involving Gsdmc3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

19
cDNA Data

3
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

57
RefSeq

38
UniProt

1
CCDS

CCDS37088.1

Ensembl

ENSMUSG00000055827 (Evidence)
NCBI Gene

270328

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055827	Ensembl Gene Model \| MGI Sequence Detail	20835	C57BL/6J	± kb
transcript	ENSMUST00000185526	Ensembl \| MGI Sequence Detail	2179	Not Applicable
polypeptide	ENSMUSP00000140272	Ensembl \| MGI Sequence Detail	480	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008389 gasdermin-C3

(term hierarchy)
InterPro Domains

IPR040460 Gasdermin, pore forming domain

IPR041263 Gasdermin, PUB domain

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All nucleic 4

cDNA 4

Microarray probesets 1

Summaries

All 42

Developmental Gene Expression 2

Diseases 1

Gene Ontology 4

Phenotypes 24
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:349394 Fattinger SA, et al., Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2315503120

TSS for Gsdmc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4610	Chr15:63750397-63750398 (-)	9 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24