Tor1aip2 MGI Mouse Gene Detail - MGI:3582695 - torsin A interacting protein 2

Symbol

Tor1aip2
Name

torsin A interacting protein 2
Synonyms

1110020D10Rik, 15kDa, Ifrg15, LULL1

Feature Type

protein coding gene
IDs

MGI:3582695
NCBI Gene: 240832
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr1:155911410-155944607 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 67.70 cM, cytoband G3
Mapping Data

4 experiments

SNPs within 2kb

844 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3582695	protein coding gene	Chr1:155911149-155944607 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016619	protein coding gene	Chr1:160996620-161031373 (+)
A/J	MGP_AJ_G0016600	protein coding gene	Chr1:154534424-154572407 (+)
AKR/J	MGP_AKRJ_G0016566	protein coding gene	Chr1:159262354-159297548 (+)
BALB/cJ	MGP_BALBcJ_G0016561	protein coding gene	Chr1:155038338-155072222 (+)
C3H/HeJ	MGP_C3HHeJ_G0016385	protein coding gene	Chr1:159386984-159422831 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017022	protein coding gene	Chr1:166530259-166563476 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014731	protein coding gene	Chr1:146750296-146784047 (+)
CAST/EiJ	MGP_CASTEiJ_G0015965	protein coding gene	Chr1:158929404-158963072 (+)
CBA/J	MGP_CBAJ_G0016360	protein coding gene	Chr1:172367524-172410356 (+)
DBA/2J	MGP_DBA2J_G0016466	protein coding gene	Chr1:153497840-153531685 (+)
FVB/NJ	MGP_FVBNJ_G0016464	protein coding gene	Chr1:151958526-151992229 (+)
LP/J	MGP_LPJ_G0016537	protein coding gene	Chr1:162135529-162171244 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016489	protein coding gene	Chr1:179958136-180005456 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017058	protein coding gene	Chr1:159068689-159102978 (+)
PWK/PhJ	MGP_PWKPhJ_G0015751	protein coding gene	Chr1:152570502-152605308 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015538	protein coding gene	Chr1:157820709-157854946 (+)
WSB/EiJ	MGP_WSBEiJ_G0016027	protein coding gene	Chr1:159163552-159202278 (+)

Human Ortholog

TOR1AIP2, torsin 1A interacting protein 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TOR1AIP2, torsin 1A interacting protein 2
Synonyms

IFRG15, LULL1, NET9
Links

HGNC:24055

NCBI Gene ID: 163590

neXtProt AC: NX_Q8NFQ8, NX_Q9H496

UniProt: Q8NFQ8, Q9H496
Chr Location

1q25.2; chr1:179839967-179877803 (-) GRCh38

MGI Vertebrate Homology

Tor1aip2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TOR1AIP2
Gene Tree

Tor1aip2

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
11 phenotype references

All Mutations and Alleles

73
Chemically induced (other)

2
Gene trapped

66
Targeted

5
Genomic Mutations

2 involving Tor1aip2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

97 strains or lines available

Mice with loss of expression in the liver are viable and do not develop hepatic steatosis.

less

All GO Annotations

12
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

787
Tissues

52
cDNA Data

32
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tor1aip2

less

All Sequences

122
RefSeq

34
UniProt

4
CCDS

CCDS15388.1, CCDS15389.1

Ensembl

ENSMUSG00000050565 (Evidence)
NCBI Gene

240832

			Length	Strain/Species	Flank
genomic	240832	NCBI Gene Model \| MGI Sequence Detail	33198	C57BL/6J	± kb
transcript	NM_172843	RefSeq \| MGI Sequence Detail	5857	C57BL/6
polypeptide	Q8BYU6	UniProt \| EBI \| MGI Sequence Detail	502	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000016552 torsin-1A-interacting protein 2

(term hierarchy)
InterPro Domains

IPR038599 LAP1C-like, C-terminal domain superfamily

IPR008662 Torsin-1A-interacting protein 1/2

IPR046753 Torsin-1A-interacting protein 1/2, AAA+ activator domain

IPR046754 Torsin-1A-interacting protein 1/2, N-terminal
GlyGen

Q8BYU6 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)

less

All nucleic 36

cDNA 34

Primer pair 1

Other 1

Microarray probesets 11

less

MGI:1915073, MGI:1929890, MGI:2138554, MGI:2138622, MGI:2138663, MGI:3034941

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 3

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345574 Hernandez-Ono A, et al., Dynamic regulation of hepatic lipid metabolism by torsinA and its activators. JCI Insight. 2024 Jan 9;:e175328

TSS for Tor1aip2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9544	Chr1:155911138-155911177 (+)	-252 bp
Tssr9545	Chr1:155911451-155911509 (+)	70 bp
Tssr9546	Chr1:155911521-155911534 (+)	118 bp
Tssr9547	Chr1:155911934-155912004 (+)	559 bp
Tssr9548	Chr1:155916630-155916644 (+)	5,227 bp
Tssr9549	Chr1:155916655-155916671 (+)	5,253 bp
Tssr9550	Chr1:155916826-155916854 (+)	5,430 bp
Tssr9551	Chr1:155919997-155919998 (+)	8,588 bp
Tssr9552	Chr1:155927132-155927139 (+)	15,726 bp
Tssr9553	Chr1:155927179-155927200 (+)	15,780 bp
Tssr9554	Chr1:155928045-155928059 (+)	16,642 bp
Tssr9555	Chr1:155928194-155928220 (+)	16,797 bp
Tssr9556	Chr1:155943214-155943219 (+)	31,807 bp
Tssr9557	Chr1:155943577-155943580 (+)	32,169 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24