Chmp6 MGI Mouse Gene Detail - MGI:3583942 - charged multivesicular body protein 6

Symbol

Chmp6
Name

charged multivesicular body protein 6
Synonyms

2400004G01Rik, chromatin modifying protein 6

Feature Type

protein coding gene
IDs

MGI:3583942
NCBI Gene: 208092
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:119804267-119810374 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 83.96 cM
Mapping Data

2 experiments

SNPs within 2kb

241 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3583942	protein coding gene	Chr11:119803874-119810378 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019486	protein coding gene	Chr11:124335824-124341532 (+)
A/J	MGP_AJ_G0019454	protein coding gene	Chr11:118815571-118821279 (+)
AKR/J	MGP_AKRJ_G0019424	protein coding gene	Chr11:122395141-122400849 (+)
BALB/cJ	MGP_BALBcJ_G0019429	protein coding gene	Chr11:119171478-119177186 (+)
C3H/HeJ	MGP_C3HHeJ_G0019235	protein coding gene	Chr11:122712855-122718563 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019878	protein coding gene	Chr11:128106860-128112568 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017503	protein coding gene	Chr11:115818989-115824646 (+)
CAST/EiJ	MGP_CASTEiJ_G0018789	protein coding gene	Chr11:124190108-124195336 (+)
CBA/J	MGP_CBAJ_G0019206	protein coding gene	Chr11:133116170-133121878 (+)
DBA/2J	MGP_DBA2J_G0019318	protein coding gene	Chr11:118182013-118187721 (+)
FVB/NJ	MGP_FVBNJ_G0019310	protein coding gene	Chr11:117866736-117872444 (+)
LP/J	MGP_LPJ_G0019390	protein coding gene	Chr11:124653219-124658926 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019343	protein coding gene	Chr11:131991343-131997051 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019917	protein coding gene	Chr11:123072557-123078265 (+)
PWK/PhJ	MGP_PWKPhJ_G0018555	protein coding gene	Chr11:119607037-119613147 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018347	protein coding gene	Chr11:122841203-122847352 (+)
WSB/EiJ	MGP_WSBEiJ_G0018841	protein coding gene	Chr11:123066403-123072111 (+)

Human Ortholog

CHMP6, charged multivesicular body protein 6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHMP6, charged multivesicular body protein 6
Synonyms

VPS20
Links

HGNC:25675

NCBI Gene ID: 79643

neXtProt AC: NX_Q96FZ7

UniProt: Q96FZ7
Chr Location

17q25.3; chr17:80991598-81009517 (+) GRCh38

MGI Vertebrate Homology

Chmp6 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CHMP6
Gene Tree

Chmp6

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

61
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

39
cDNA Data

60
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chmp6

ZFIN chmp6b

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All Sequences

61
RefSeq

4
UniProt

6
CCDS

CCDS36385.1

Ensembl

ENSMUSG00000025371 (Evidence)
NCBI Gene

208092

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025371	Ensembl Gene Model \| MGI Sequence Detail	6108	C57BL/6J	± kb
transcript	ENSMUST00000026434	Ensembl \| MGI Sequence Detail	1557	Not Applicable
polypeptide	ENSMUSP00000026434	Ensembl \| MGI Sequence Detail	200	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005440 charged multivesicular body protein 6

(term hierarchy)
InterPro Domains

IPR005024 Snf7 family

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All nucleic 62

cDNA 60

Primer pair 2

Microarray probesets 3

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MGI:1916965

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Chmp6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106258	Chr11:119804249-119804260 (+)	-12 bp
Tssr106259	Chr11:119804628-119804680 (+)	387 bp
Tssr106260	Chr11:119807129-119807163 (+)	2,879 bp
Tssr106261	Chr11:119807473-119807509 (+)	3,224 bp
Tssr3753	Chr11:119807522-119807533 (+)	3,261 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24