Cdk15 MGI Mouse Gene Detail - MGI:3583944 - cyclin dependent kinase 15

Symbol

Cdk15
Name

cyclin dependent kinase 15
Synonyms

Als2cr7, Pftk2

Feature Type

protein coding gene
IDs

MGI:3583944
NCBI Gene: 271697
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:59296029-59391656 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 29.47 cM
Mapping Data

1 experiment

SNPs within 2kb

2560 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3583944	protein coding gene	Chr1:59296029-59392152 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016065	protein coding gene	Chr1:59209497-59307819 (+)
A/J	MGP_AJ_G0016048	protein coding gene	Chr1:57154004-57247576 (+)
AKR/J	MGP_AKRJ_G0016004	protein coding gene	Chr1:58752719-58848855 (+)
BALB/cJ	MGP_BALBcJ_G0016003	protein coding gene	Chr1:57194154-57286915 (+)
C3H/HeJ	MGP_C3HHeJ_G0015835	protein coding gene	Chr1:58999169-59098153 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016456	protein coding gene	Chr1:61559502-61653737 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014177	protein coding gene	Chr1:52973459-53066182 (+)
CAST/EiJ	MGP_CASTEiJ_G0015417	protein coding gene	Chr1:58141333-58248563 (+)
CBA/J	MGP_CBAJ_G0015807	protein coding gene	Chr1:63475863-63578404 (+)
DBA/2J	MGP_DBA2J_G0015908	protein coding gene	Chr1:56577210-56678281 (+)
FVB/NJ	MGP_FVBNJ_G0015910	protein coding gene	Chr1:55883458-55977841 (+)
LP/J	MGP_LPJ_G0015980	protein coding gene	Chr1:60108305-60208202 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015930	protein coding gene	Chr1:66398840-66496230 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016503	protein coding gene	Chr1:58658740-58759467 (+)
PWK/PhJ	MGP_PWKPhJ_G0015204	protein coding gene	Chr1:55919400-56013419 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014984	protein coding gene	Chr1:58184963-58281322 (+)
WSB/EiJ	MGP_WSBEiJ_G0015480	protein coding gene	Chr1:58365886-58466125 (+)

Human Ortholog

CDK15, cyclin dependent kinase 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK15, cyclin dependent kinase 15
Synonyms

ALS2CR7, PFTAIRE2, PFTK2
Links

HGNC:14434

NCBI Gene ID: 65061

neXtProt AC: NX_Q96Q40

UniProt: Q96Q40
Chr Location

2q33.1; chr2:201790461-201895550 (+) GRCh38

MGI Vertebrate Homology

Cdk15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDK15
Gene Tree

Cdk15

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

3
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Cdk15
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdk15

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All Sequences

52
RefSeq

11
UniProt

2
CCDS

CCDS48273.1

Ensembl

ENSMUSG00000026023 (Evidence)
NCBI Gene

271697

			Length	Strain/Species	Flank
genomic	271697	NCBI Gene Model \| MGI Sequence Detail	95628	C57BL/6J	± kb
transcript	NM_001033373	RefSeq \| MGI Sequence Detail	4361	C57BL/6
polypeptide	Q3V3A1	UniProt \| EBI \| MGI Sequence Detail	433	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012590 cyclin-dependent kinase 15

(term hierarchy)
EC

2.7.11.22
InterPro Domains

IPR042761 CDK15, catalytic domain

IPR050108 Cyclin-dependent kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 7

cDNA 7

Microarray probesets 1

Summaries

All 36

Gene Ontology 7

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdk15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6864	Chr1:59338079-59338098 (+)	42,060 bp
Tssr6865	Chr1:59354432-59354447 (+)	58,411 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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