Atxn7l1 Gene Detail

Summary

• Symbol
  Atxn7l1
• Name
  ataxin 7-like 1
• Synonyms
  2810423G08Rik, Atxn7l4

• Feature Type
  protein coding gene
• IDs
  MGI:3584458
  NCBI Gene: 380753
• Alliance
  gene page
• Transcription Start Sites
  22 TSS

Location &
Maps

• Sequence Map
  Chr12:33197692-33423184 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 14.03 cM, cytoband B2
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  5902 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3584458	protein coding gene	Chr12:33196967-33426407 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019674	protein coding gene	Chr12:31212523-31438294 (+)
A/J	MGP_AJ_G0019641	protein coding gene	Chr12:30274734-30503461 (+)
AKR/J	MGP_AKRJ_G0019612	protein coding gene	Chr12:31264435-31491758 (+)
BALB/cJ	MGP_BALBcJ_G0019618	protein coding gene	Chr12:30500444-30722937 (+)
C3H/HeJ	MGP_C3HHeJ_G0019422	protein coding gene	Chr12:31115042-31345079 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020065	protein coding gene	Chr12:32132457-32377420 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017690	protein coding gene	Chr12:29562973-29784506 (+)
CAST/EiJ	MGP_CASTEiJ_G0018977	protein coding gene	Chr12:26157399-26401075 (+)
CBA/J	MGP_CBAJ_G0019394	protein coding gene	Chr12:33172689-33416453 (+)
DBA/2J	MGP_DBA2J_G0019507	protein coding gene	Chr12:30094076-30321035 (+)
FVB/NJ	MGP_FVBNJ_G0019498	protein coding gene	Chr12:29882081-30112967 (+)
LP/J	MGP_LPJ_G0019577	protein coding gene	Chr12:31284726-31515658 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019533	protein coding gene	Chr12:32799416-33033524 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020105	protein coding gene	Chr12:30764856-30992491 (+)
PWK/PhJ	MGP_PWKPhJ_G0018744	protein coding gene	Chr12:24868413-25096229 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018532	protein coding gene	Chr12:25390793-25633896 (+)
WSB/EiJ	MGP_WSBEiJ_G0019027	protein coding gene	Chr12:31010684-31239192 (+)

Homology

• Human Ortholog
  ATXN7L1, ataxin 7 like 1

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ATXN7L1, ataxin 7 like 1
  
• Synonyms
  ATXN7L4
• Links
  HGNC:22210

  NCBI Gene ID: 222255

  neXtProt AC: NX_Q9ULK2

  UniProt: Q9ULK2

  
  
• Chr Location
  7q22.3

---

• MGI Vertebrate Homology
  Atxn7l1 stringent orthology
  1 human;1 mouse;1 zebrafish
  
• HCOP
  vertebrate homology predictions: ATXN7L1
• Gene Tree
  Atxn7l1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  7 phenotype references
  

• All Mutations and Alleles
  12
• Endonuclease-mediated
  2
• Gene trapped
  10
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  36 strains or lines available

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  706
• cDNA Data
  12

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase atxn7l1

Sequences &
Gene Models

• All Sequences
  115
• RefSeq
  48
• UniProt
  9
• CCDS
  CCDS25874.2, CCDS25875.1

• Ensembl
  ENSMUSG00000020564 (Evidence)
• NCBI Gene
  380753

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000020564	Ensembl Gene Model | MGI Sequence Detail	225493	C57BL/6J
transcript	ENSMUST00000146040	Ensembl | MGI Sequence Detail	2973	Not Applicable
polypeptide	ENSMUSP00000122156	Ensembl | MGI Sequence Detail	927	Not Applicable

Protein
Information

• UniProt
  9 Sequences
• Protein Ontology
  PR:000004509 ataxin-7-like protein 1
  (term hierarchy)
• InterPro Domains
  IPR052237 Ataxin-7-like transcription regulator
  IPR013243 SCA7 domain
• GlyGen
  Q9CZ05 1 site, 1 N-linked glycan (1 site)

Molecular
Reagents

• All nucleic 13

  Genomic 1

  cDNA 12

  
  

  Microarray probesets 6

Other
Accession IDs

MGI:1919424

References

• Summaries
  All 28

  Phenotypes 7
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Atxn7l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113175	Chr12:33196955-33196993 (+)	-718 bp
Tssr113176	Chr12:33196994-33197003 (+)	-693 bp
Tssr113177	Chr12:33197699-33197715 (+)	15 bp
Tssr113178	Chr12:33197754-33197769 (+)	70 bp
Tssr113179	Chr12:33197770-33197819 (+)	103 bp
Tssr113180	Chr12:33257669-33257670 (+)	59,978 bp
Tssr113181	Chr12:33300122-33300153 (+)	102,446 bp
Tssr113182	Chr12:33352245-33352265 (+)	154,563 bp
Tssr113183	Chr12:33363988-33364018 (+)	166,311 bp
Tssr113184	Chr12:33364261-33364287 (+)	166,582 bp
Tssr113185	Chr12:33364288-33364327 (+)	166,616 bp
Tssr113186	Chr12:33364332-33364367 (+)	166,658 bp
Tssr113187	Chr12:33364374-33364407 (+)	166,699 bp
Tssr113188	Chr12:33365392-33365410 (+)	167,709 bp
Tssr113189	Chr12:33365411-33365446 (+)	167,737 bp
Tssr113190	Chr12:33365489-33365500 (+)	167,803 bp
Tssr113191	Chr12:33365512-33365525 (+)	167,827 bp
Tssr113192	Chr12:33383152-33383154 (+)	185,461 bp
Tssr113193	Chr12:33383234-33383249 (+)	185,550 bp
Tssr113194	Chr12:33387412-33387424 (+)	189,726 bp
Tssr113195	Chr12:33387507-33387510 (+)	189,817 bp
Tssr113196	Chr12:33398401-33398407 (+)	200,712 bp