Wdfy4 MGI Mouse Gene Detail - MGI:3584510 - WD repeat and FYVE domain containing 4

Symbol

Wdfy4
Name

WD repeat and FYVE domain containing 4

Feature Type

protein coding gene
IDs

MGI:3584510
NCBI Gene: 545030
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:32681504-32907465 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 19.44 cM
Mapping Data

1 experiment

SNPs within 2kb

7005 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3584510	protein coding gene	Chr14:32681504-32915809 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021153	protein coding gene	Chr14:26237754-26484853 (-)
A/J	MGP_AJ_G0021101	protein coding gene	Chr14:25232876-25466254 (-)
AKR/J	MGP_AKRJ_G0021078	protein coding gene	Chr14:26381205-26608874 (-)
BALB/cJ	MGP_BALBcJ_G0021105	protein coding gene	Chr14:25408881-25635861 (-)
C3H/HeJ	MGP_C3HHeJ_G0020888	protein coding gene	Chr14:26272592-26508195 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021537	protein coding gene	Chr14:27264470-27500496 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019099	protein coding gene	Chr14:25285924-25504804 (-)
CAST/EiJ	MGP_CASTEiJ_G0020413	protein coding gene	Chr14:26084305-26330709 (-)
CBA/J	MGP_CBAJ_G0020855	protein coding gene	Chr14:28283813-28546904 (-)
DBA/2J	MGP_DBA2J_G0020977	protein coding gene	Chr14:25278999-25506411 (-)
FVB/NJ	MGP_FVBNJ_G0020961	protein coding gene	Chr14:25221512-25448178 (-)
LP/J	MGP_LPJ_G0021046	protein coding gene	Chr14:26554326-26800745 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020987	protein coding gene	Chr14:27471282-27717469 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021570	protein coding gene	Chr14:26184653-26424684 (-)
PWK/PhJ	MGP_PWKPhJ_G0020161	protein coding gene	Chr14:24742930-24975427 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019985	protein coding gene	Chr14:25819200-26070314 (-)
WSB/EiJ	MGP_WSBEiJ_G0020468	protein coding gene	Chr14:26253794-26500981 (-)

Human Ortholog

WDFY4, WDFY family member 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WDFY4, WDFY family member 4
Synonyms

C10orf64
Links

HGNC:29323

NCBI Gene ID: 57705

neXtProt AC: NX_Q6ZS81

UniProt: Q6ZS81
Chr Location

10q11.23; chr10:48684873-48982956 (+) GRCh38

MGI Vertebrate Homology

Wdfy4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WDFY4
Gene Tree

Wdfy4

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

142 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced CD103+ CD11b^neg migratory cDC1 cells in the mesenteric lymph nodes and failure to reject 1969 sarcoma cells.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

28

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wdfy4

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All Sequences

60
RefSeq

16
UniProt

6
CCDS

CCDS49441.1

Ensembl

ENSMUSG00000051506 (Evidence)
NCBI Gene

545030

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051506	Ensembl Gene Model \| MGI Sequence Detail	225962	C57BL/6J	± kb
transcript	ENSMUST00000130509	Ensembl \| MGI Sequence Detail	10158	Not Applicable
polypeptide	ENSMUSP00000117068	Ensembl \| MGI Sequence Detail	3183	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000017385 WD repeat- and FYVE domain-containing protein 4

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR000409 BEACH domain

IPR051944 BEACH domain-containing protein

IPR036372 BEACH domain superfamily

IPR020472 G-protein beta WD-40 repeat

IPR023362 PH-BEACH domain

IPR011993 PH-like domain superfamily

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 28

cDNA 28

Microarray probesets 4

Summaries

All 31

Gene Ontology 4

Phenotypes 10
Earliest

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Wdfy4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128028	Chr14:32907446-32907514 (-)	-15 bp
Tssr128027	Chr14:32907131-32907145 (-)	327 bp
Tssr128026	Chr14:32907096-32907123 (-)	355 bp
Tssr128025	Chr14:32907072-32907088 (-)	385 bp
Tssr128024	Chr14:32907037-32907057 (-)	418 bp
Tssr128023	Chr14:32884911-32884924 (-)	22,547 bp
Tssr128022	Chr14:32847232-32847236 (-)	60,231 bp
Tssr128021	Chr14:32834207-32834219 (-)	73,252 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24