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Rtl4 Gene Detail
Summary
  • Symbol
    Rtl4
  • Name
    retrotransposon Gag like 4
  • Synonyms
    C230031A03Rik, Mar4, Zcchc16
  • Feature Type
    protein coding gene
  • IDs
    MGI:3588192
    NCBI Gene: 619287
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:143471903-143905407 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 65.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    9519 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3588192
 protein coding gene ChrX:143471147-143905410 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036160
 protein coding gene ChrX:142249392-142680309 (+)
A/J MGP_AJ_G0036137
 protein coding gene ChrX:141579585-142012021 (+)
AKR/J MGP_AKRJ_G0036063
 protein coding gene ChrX:146183755-146635585 (+)
BALB/cJ MGP_BALBcJ_G0036128
 protein coding gene ChrX:139815216-140219237 (+)
C3H/HeJ MGP_C3HHeJ_G0035836
 protein coding gene ChrX:142367188-142798259 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036652
 protein coding gene ChrX:146269500-146717568 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033475
 protein coding gene ChrX:133494571-133514685 (+)
CAST/EiJ MGP_CASTEiJ_G0035127
 protein coding gene ChrX:122991430-123392508 (+)
CBA/J MGP_CBAJ_G0035813
 protein coding gene ChrX:150780389-151242098 (+)
DBA/2J MGP_DBA2J_G0035971
 protein coding gene ChrX:140643168-141084218 (+)
FVB/NJ MGP_FVBNJ_G0035905
 protein coding gene ChrX:139861643-140287047 (+)
LP/J MGP_LPJ_G0036062
 protein coding gene ChrX:143206309-143632510 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035941
 protein coding gene ChrX:158581096-159084617 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036688
 protein coding gene ChrX:141555494-141960073 (+)
PWK/PhJ MGP_PWKPhJ_G0034821
 protein coding gene ChrX:120130670-120151526 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034647
 protein coding gene ChrX:123543087-123947398 (+)
WSB/EiJ MGP_WSBEiJ_G0035262
 protein coding gene ChrX:139900079-140323736 (+)



Homology
more
  • Human Ortholog
    RTL4, retrotransposon Gag like 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTL4, retrotransposon Gag like 4
  • Synonyms
    Mar4, Mart4, SIRH1, SIRH11, ZCCHC16
  • Links
    NCBI Gene ID: 340595
    neXtProt AC: NX_Q6ZR62
    UniProt: Q6ZR62

  • Chr Location
    Xq23; chrX:112083013-112457514 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit abnormal behavior including hyperactivity and abnormal responses to a new environment, and abnormal working memory and cognition. Neuronal norepinephrine levesl are slow to recover after induced neurotransmitter release. Mortality, growth, kidney function, and reproductive system biology are all unaffected.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    4
  • GO References
    2
Molecular Function

Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    28
  • cDNA Data
    6
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071679 Ensembl Gene Model | MGI Sequence Detail 433505 C57BL/6J ±  kb
transcript ENSMUST00000096301 Ensembl | MGI Sequence Detail 1758 Not Applicable  
polypeptide ENSMUSP00000108463 Ensembl | MGI Sequence Detail 304 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 6
    Primer pair 2

    Microarray probesets 1
Other
Accession IDs
less
MGI:5906148
References
more
  • Summaries
    All 21
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:96508 Brandt J, et al., Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. Gene. 2005 Jan 17;345(1):101-11
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory