Ube2u MGI Mouse Gene Detail - MGI:3588216 - ubiquitin-conjugating enzyme E2U (putative)

Symbol

Ube2u
Name

ubiquitin-conjugating enzyme E2U (putative)

Feature Type

protein coding gene
IDs

MGI:3588216
NCBI Gene: 381534
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:100336064-100407342 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 45.72 cM
Mapping Data

1 experiment

SNPs within 2kb

1869 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3588216	protein coding gene	Chr4:100336046-100407344 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028487	protein coding gene	Chr4:100751339-100824526 (+)
A/J	MGP_AJ_G0028450	protein coding gene	Chr4:97230670-97300739 (+)
AKR/J	MGP_AKRJ_G0028397	protein coding gene	Chr4:99565474-99640840 (+)
BALB/cJ	MGP_BALBcJ_G0028468	protein coding gene	Chr4:97466501-97540190 (+)
C3H/HeJ	MGP_C3HHeJ_G0028181	protein coding gene	Chr4:100404188-100475130 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028907	protein coding gene	Chr4:104572639-104647378 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026199	protein coding gene	Chr4:92570967-92641730 (+)
CAST/EiJ	MGP_CASTEiJ_G0027621	protein coding gene	Chr4:98187433-98257974 (+)
CBA/J	MGP_CBAJ_G0028150	protein coding gene	Chr4:107847098-107925261 (+)
DBA/2J	MGP_DBA2J_G0028300	protein coding gene	Chr4:96935592-97010575 (+)
FVB/NJ	MGP_FVBNJ_G0028267	protein coding gene	Chr4:95777386-95846681 (+)
LP/J	MGP_LPJ_G0028400	protein coding gene	Chr4:101055036-101125197 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028295	protein coding gene	Chr4:113435221-113507418 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028945	protein coding gene	Chr4:99841906-99917018 (+)
PWK/PhJ	MGP_PWKPhJ_G0027346	protein coding gene	Chr4:95105609-95176436 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027168	protein coding gene	Chr4:97296981-97370872 (+)
WSB/EiJ	MGP_WSBEiJ_G0027699	protein coding gene	Chr4:99997996-100073636 (+)

Human Ortholog

UBE2U, ubiquitin conjugating enzyme E2 U

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2U, ubiquitin conjugating enzyme E2 U
Links

HGNC:28559

NCBI Gene ID: 148581

neXtProt AC: NX_Q5VVX9

UniProt: Q5VVX9
Chr Location

1p31.3; chr1:64203623-64267368 (+) GRCh38

MGI Vertebrate Homology

Ube2u stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: UBE2U
Gene Tree

Ube2u

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Ube2u
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available

Male mice homozygous for a mutation are viable and show normal fertility.

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All GO Annotations

5
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

4
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS18390.2

Ensembl

ENSMUSG00000069733 (Evidence)
NCBI Gene

381534

			Length	Strain/Species	Flank
genomic	381534	NCBI Gene Model \| MGI Sequence Detail	71279	C57BL/6J	± kb
transcript	NM_001033773	RefSeq \| MGI Sequence Detail	1573	C57BL/6
polypeptide	NP_001028945	RefSeq \| MGI Sequence Detail	352	C57BL/6

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UniProt

3 Sequences
InterPro Domains

IPR050113 Ubiquitin-conjugating enzyme

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

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All nucleic 9

cDNA 9

Microarray probesets 3

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 15
Earliest

J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ube2u:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37964	Chr4:100335992-100335999 (+)	-68 bp
Tssr37965	Chr4:100336003-100336069 (+)	-28 bp
Tssr37966	Chr4:100336325-100336343 (+)	270 bp
Tssr37967	Chr4:100336347-100336367 (+)	293 bp
Tssr37968	Chr4:100336373-100336378 (+)	312 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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