Flrt2 MGI Mouse Gene Detail - MGI:3603594 - fibronectin leucine rich transmembrane protein 2

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Flrt2 Gene Detail

Symbol

Flrt2
Name

fibronectin leucine rich transmembrane protein 2

Feature Type

protein coding gene
IDs

MGI:3603594
NCBI Gene: 399558
Alliance

gene page
Transcription Start Sites

26 TSS

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Sequence Map

Chr12:95659000-95751989 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 46.44 cM
Mapping Data

1 experiment

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SNPs within 2kb

3274 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_3603594	protein coding gene	Chr12:95658780-95751989 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020002	protein coding gene	Chr12:96959830-97055025 (+)
A/J	MGP_AJ_G0019957	protein coding gene	Chr12:93270238-93364850 (+)
AKR/J	MGP_AKRJ_G0019933	protein coding gene	Chr12:95858348-95952018 (+)
BALB/cJ	MGP_BALBcJ_G0019943	protein coding gene	Chr12:93661921-93756640 (+)
C3H/HeJ	MGP_C3HHeJ_G0019745	protein coding gene	Chr12:96390968-96487803 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020392	protein coding gene	Chr12:99872571-99975217 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018006	protein coding gene	Chr12:90484228-90577545 (+)
CAST/EiJ	MGP_CASTEiJ_G0019291	protein coding gene	Chr12:91413128-91510983 (+)
CBA/J	MGP_CBAJ_G0019717	protein coding gene	Chr12:103628705-103730307 (+)
DBA/2J	MGP_DBA2J_G0019828	protein coding gene	Chr12:92745231-92841264 (+)
FVB/NJ	MGP_FVBNJ_G0019817	protein coding gene	Chr12:91530217-91626811 (+)
LP/J	MGP_LPJ_G0019904	protein coding gene	Chr12:96785135-96883736 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019859	protein coding gene	Chr12:107001459-107099860 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020421	protein coding gene	Chr12:95392986-95491152 (+)
PWK/PhJ	MGP_PWKPhJ_G0019055	protein coding gene	Chr12:87378194-87473443 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018851	protein coding gene	Chr12:89585411-89688393 (+)
WSB/EiJ	MGP_WSBEiJ_G0019345	protein coding gene	Chr12:96245694-96341337 (+)

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Human Ortholog

FLRT2, fibronectin leucine rich transmembrane protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FLRT2, fibronectin leucine rich transmembrane protein 2
Links

HGNC:3761

NCBI Gene ID: 23768

neXtProt AC: NX_O43155

UniProt: O43155
Chr Location

14q31.3; chr14:85530144-85654428 (+) GRCh38

MGI Vertebrate Homology

Flrt2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FLRT2
Gene Tree

Flrt2

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

7
Genomic Mutations

1 involving Flrt2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic, fetal, and postnatel lethality with few mice surviving to weaning due to defects in epicardium, myocardium, and endocardium development.

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All GO Annotations

23
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

840
Tissues

111
cDNA Data

91
Literature Summary

26

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FLRT2

Xenbase flrt2

ZFIN si:dkey-87k14.1

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All Sequences

52
RefSeq

10
UniProt

2
CCDS

CCDS26094.1

Ensembl

ENSMUSG00000047414 (Evidence)
NCBI Gene

399558

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000047414	Ensembl Gene Model \| MGI Sequence Detail	92990	C57BL/6J	± kb
	transcript	ENSMUST00000057324	Ensembl \| MGI Sequence Detail	7099	Not Applicable
	polypeptide	ENSMUSP00000062171	Ensembl \| MGI Sequence Detail	660	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007561 leucine-rich repeat transmembrane protein FLRT2

(term hierarchy)
PDB

4V2C, 4V2D, 5FTT, 5FTU
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype

IPR050333 Small Leucine-Rich Proteoglycans
GlyGen

Q8BLU0 1 site, 1 N-linked glycan (1 site)

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All nucleic 94

cDNA 92

Primer pair 2

Microarray probesets 3

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Summaries

All 64

Developmental Gene Expression 26

Gene Ontology 11

Phenotypes 19
Earliest

J:112631 Haines BP, et al., Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Dev Biol. 2006 Sep 1;297(1):14-25
Latest

J:348278 Liakath-Ali K, et al., Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development. PLoS Biol. 2024 May;22(5):e3002599

TSS for Flrt2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114605	Chr12:95658969-95658981 (+)	-25 bp
Tssr114606	Chr12:95658986-95659020 (+)	3 bp
Tssr114607	Chr12:95659022-95659032 (+)	27 bp
Tssr114608	Chr12:95659087-95659098 (+)	93 bp
Tssr114609	Chr12:95659103-95659118 (+)	111 bp
Tssr114610	Chr12:95661964-95661969 (+)	2,967 bp
Tssr114611	Chr12:95662124-95662139 (+)	3,132 bp
Tssr114612	Chr12:95662166-95662171 (+)	3,169 bp
Tssr114613	Chr12:95662200-95662220 (+)	3,210 bp
Tssr114614	Chr12:95662230-95662282 (+)	3,256 bp
Tssr114615	Chr12:95662287-95662300 (+)	3,294 bp
Tssr114616	Chr12:95667886-95667893 (+)	8,890 bp
Tssr114617	Chr12:95669804-95669832 (+)	10,818 bp
Tssr114618	Chr12:95676476-95676480 (+)	17,478 bp
Tssr114619	Chr12:95695104-95695116 (+)	36,110 bp
Tssr114620	Chr12:95706968-95706972 (+)	47,970 bp
Tssr114621	Chr12:95713898-95713902 (+)	54,900 bp
Tssr114622	Chr12:95714826-95714840 (+)	55,833 bp
Tssr114623	Chr12:95717017-95717031 (+)	58,024 bp
Tssr114624	Chr12:95717099-95717110 (+)	58,105 bp
Tssr114625	Chr12:95717193-95717206 (+)	58,200 bp
Tssr114626	Chr12:95727185-95727191 (+)	68,188 bp
Tssr114627	Chr12:95745853-95745858 (+)	86,856 bp
Tssr114628	Chr12:95747367-95747381 (+)	88,374 bp
Tssr114629	Chr12:95747554-95747568 (+)	88,561 bp
Tssr114630	Chr12:95749381-95749384 (+)	90,383 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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