Gpat3 MGI Mouse Gene Detail - MGI:3603816 - glycerol-3-phosphate acyltransferase 3

Symbol

Gpat3
Name

glycerol-3-phosphate acyltransferase 3
Synonyms

4933407I02Rik, A230097K15Rik, Agpat9

Feature Type

protein coding gene
IDs

MGI:3603816
NCBI Gene: 231510
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:100994095-101046968 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 48.52 cM
Mapping Data

2 experiments

SNPs within 2kb

1845 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3603816	protein coding gene	Chr5:100993579-101046968 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029794	protein coding gene	Chr5:102360562-102416156 (+)
A/J	MGP_AJ_G0029760	protein coding gene	Chr5:98543382-98597173 (+)
AKR/J	MGP_AKRJ_G0029706	protein coding gene	Chr5:101782871-101840931 (+)
BALB/cJ	MGP_BALBcJ_G0029770	protein coding gene	Chr5:99571770-99624563 (+)
C3H/HeJ	MGP_C3HHeJ_G0029493	protein coding gene	Chr5:102131095-102185107 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030225	protein coding gene	Chr5:106617486-106679558 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027460	protein coding gene	Chr5:93786894-93838613 (+)
CAST/EiJ	MGP_CASTEiJ_G0028904	protein coding gene	Chr5:100797028-100861059 (+)
CBA/J	MGP_CBAJ_G0029463	protein coding gene	Chr5:110313411-110366785 (+)
DBA/2J	MGP_DBA2J_G0029607	protein coding gene	Chr5:98736699-98789276 (+)
FVB/NJ	MGP_FVBNJ_G0029566	protein coding gene	Chr5:97534700-97586885 (+)
LP/J	MGP_LPJ_G0029695	protein coding gene	Chr5:102972413-103025054 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029595	protein coding gene	Chr5:115370702-115426916 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030258	protein coding gene	Chr5:101271028-101323333 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0028457	protein coding gene	Chr5:98940838-98995408 (+)
WSB/EiJ	MGP_WSBEiJ_G0028982	protein coding gene	Chr5:101606087-101672060 (+)

Human Ortholog

GPAT3, glycerol-3-phosphate acyltransferase 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPAT3, glycerol-3-phosphate acyltransferase 3
Synonyms

AGPAT 10, AGPAT10, AGPAT8, AGPAT9, HMFN0839, LPAAT-theta, MAG1
Links

HGNC:28157

NCBI Gene ID: 84803

neXtProt AC: NX_Q53EU6

UniProt: Q53EU6
Chr Location

4q21.23; chr4:83535587-83605875 (+) GRCh38

MGI Vertebrate Homology

Gpat3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GPAT3
Gene Tree

Gpat3

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Phenotype Summary

18 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

3
Radiation induced

1
Spontaneous

1
Targeted

1
Genomic Mutations

3 involving Gpat3
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Under high-fat feeding, mice homozygous for a knock-out allele exhibit increased energy expenditure, improved glucose homeostasis, enlarged livers, increased total serum cholesterol levels, altered liver cholesterol metabolism, and female-specific protection from diet-induced obesity.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

8
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpat3

ZFIN gpat3

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All Sequences

48
RefSeq

4
UniProt

2
CCDS

CCDS19470.1

Ensembl

ENSMUSG00000029314 (Evidence)
NCBI Gene

231510

			Length	Strain/Species	Flank
genomic	231510	NCBI Gene Model \| MGI Sequence Detail	52874	C57BL/6J	± kb
transcript	NM_172715	RefSeq \| MGI Sequence Detail	2877	C57BL/6
polypeptide	Q8C0N2	UniProt \| EBI \| MGI Sequence Detail	438	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003841 glycerol-3-phosphate acyltransferase 3

(term hierarchy)
EC

2.3.1.15, 2.3.1.51
InterPro Domains

IPR045252 Lysophosphatidylcholine acyltransferase LPCAT1-like

IPR002123 Phospholipid/glycerol acyltransferase

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All nucleic 10

Genomic 2

cDNA 8

Microarray probesets 3

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MGI:1918298

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:348105 Chen H, et al., Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 20;1870(5):167189

TSS for Gpat3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47490	Chr5:100993575-100993594 (+)	-510 bp
Tssr47491	Chr5:100993740-100993748 (+)	-351 bp
Tssr47492	Chr5:100994144-100994159 (+)	57 bp
Tssr47493	Chr5:100994283-100994315 (+)	204 bp
Tssr47494	Chr5:100994316-100994374 (+)	250 bp
Tssr47495	Chr5:101009883-101009887 (+)	15,790 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24