Lpcat2 MGI Mouse Gene Detail - MGI:3606214 - lysophosphatidylcholine acyltransferase 2

Symbol

Lpcat2
Name

lysophosphatidylcholine acyltransferase 2
Synonyms

Aytl1, Aytl1a, LPCAT2, lysoPAFAT/LPCAT2

Feature Type

protein coding gene
IDs

MGI:3606214
NCBI Gene: 270084
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr8:93581967-93645907 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 44.99 cM
Mapping Data

1 experiment

SNPs within 2kb

2212 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3606214	protein coding gene	Chr8:93581948-93645907 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033937	protein coding gene	Chr8:94172143-94237940 (+)
A/J	MGP_AJ_G0033920	protein coding gene	Chr8:90458327-90522069 (+)
AKR/J	MGP_AKRJ_G0033846	protein coding gene	Chr8:93001516-93068774 (+)
BALB/cJ	MGP_BALBcJ_G0033912	protein coding gene	Chr8:90613717-90678951 (+)
C3H/HeJ	MGP_C3HHeJ_G0033622	protein coding gene	Chr8:93716845-93780648 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034433	protein coding gene	Chr8:97639288-97707780 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031374	protein coding gene	Chr8:84386477-84451089 (+)
CAST/EiJ	MGP_CASTEiJ_G0032954	protein coding gene	Chr8:93275681-93343314 (+)
CBA/J	MGP_CBAJ_G0033598	protein coding gene	Chr8:100886002-100954708 (+)
DBA/2J	MGP_DBA2J_G0033752	protein coding gene	Chr8:90003330-90066155 (+)
FVB/NJ	MGP_FVBNJ_G0033699	protein coding gene	Chr8:88942493-89005759 (+)
LP/J	MGP_LPJ_G0033844	protein coding gene	Chr8:94292787-94361190 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033741	protein coding gene	Chr8:103239358-103307716 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034451	protein coding gene	Chr8:93118835-93182772 (+)
PWK/PhJ	MGP_PWKPhJ_G0032656	protein coding gene	Chr8:89353571-89418408 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032493	protein coding gene	Chr8:91968002-92034555 (+)
WSB/EiJ	MGP_WSBEiJ_G0033066	protein coding gene	Chr8:93579858-93644524 (+)

Human Ortholog

LPCAT2, lysophosphatidylcholine acyltransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LPCAT2, lysophosphatidylcholine acyltransferase 2
Synonyms

AGPAT11, AYTL1, LPLAT9, LysoPAFAT
Links

HGNC:26032

NCBI Gene ID: 54947

neXtProt AC: NX_Q7L5N7

UniProt: Q7L5N7
Chr Location

16q12.2; chr16:55509072-55586666 (+) GRCh38

MGI Vertebrate Homology

Lpcat2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LPCAT2
Gene Tree

Lpcat2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

6
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

24
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

94
cDNA Data

20
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lpcat2

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All Sequences

49
RefSeq

7
UniProt

2
CCDS

CCDS22524.1, CCDS90434.1

Ensembl

ENSMUSG00000033192 (Evidence)
NCBI Gene

270084

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033192	Ensembl Gene Model \| MGI Sequence Detail	63941	C57BL/6J	± kb
transcript	ENSMUST00000046290	Ensembl \| MGI Sequence Detail	2811	Not Applicable
polypeptide	ENSMUSP00000049252	Ensembl \| MGI Sequence Detail	544	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009891 lysophosphatidylcholine acyltransferase 2

(term hierarchy)
EC

2.3.1.23, 2.3.1.25, 2.3.1.51, 2.3.1.67
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR045252 Lysophosphatidylcholine acyltransferase LPCAT1-like

IPR002123 Phospholipid/glycerol acyltransferase

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All nucleic 20

cDNA 20

Microarray probesets 2

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 9
Earliest

J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
Latest

J:359018 Cao N, et al., LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11 axis. Oncogene. 2024 May;43(22):1714-1725

TSS for Lpcat2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78761	Chr8:93581947-93582028 (+)	21 bp
Tssr78762	Chr8:93582032-93582043 (+)	71 bp
Tssr78763	Chr8:93591509-93591511 (+)	9,543 bp
Tssr78764	Chr8:93607408-93607423 (+)	25,449 bp
Tssr78765	Chr8:93608748-93608774 (+)	26,794 bp
Tssr78766	Chr8:93612493-93612507 (+)	30,533 bp
Tssr78767	Chr8:93614028-93614044 (+)	32,069 bp
Tssr78768	Chr8:93614077-93614085 (+)	32,114 bp
Tssr78769	Chr8:93619263-93619298 (+)	37,314 bp
Tssr78775	Chr8:93638347-93638356 (+)	56,385 bp
Tssr78776	Chr8:93638394-93638405 (+)	56,433 bp
Tssr78777	Chr8:93644952-93644955 (+)	62,987 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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