Cdnf MGI Mouse Gene Detail - MGI:3606576 - cerebral dopamine neurotrophic factor

Symbol

Cdnf
Name

cerebral dopamine neurotrophic factor
Synonyms

Armetl1

Feature Type

protein coding gene
IDs

MGI:3606576
NCBI Gene: 227526
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:3514102-3527413 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 1.99 cM
Mapping Data

1 experiment

SNPs within 2kb

447 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3606576	protein coding gene	Chr2:3514067-3527413 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025311	protein coding gene	Chr2:494866-508331 (+)
A/J	MGP_AJ_G0025287	protein coding gene	Chr2:463690-476961 (+)
AKR/J	MGP_AKRJ_G0025256	protein coding gene	Chr2:479637-492962 (+)
BALB/cJ	MGP_BALBcJ_G0025283	protein coding gene	Chr2:451598-464891 (+)
C3H/HeJ	MGP_C3HHeJ_G0025043	protein coding gene	Chr2:490065-506015 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025726	protein coding gene	Chr2:483269-500212 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023140	protein coding gene	Chr2:404066-418098 (+)
CAST/EiJ	MGP_CASTEiJ_G0024507	protein coding gene	Chr2:491343-513384 (+)
CBA/J	MGP_CBAJ_G0025023	protein coding gene	Chr2:522095-535426 (+)
DBA/2J	MGP_DBA2J_G0025154	protein coding gene	Chr2:444387-458205 (+)
FVB/NJ	MGP_FVBNJ_G0025116	protein coding gene	Chr2:456941-470746 (+)
LP/J	MGP_LPJ_G0025241	protein coding gene	Chr2:491281-504602 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025149	protein coding gene	Chr2:486046-501883 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025784	protein coding gene	Chr2:478075-491398 (+)
PWK/PhJ	MGP_PWKPhJ_G0024256	protein coding gene	Chr2:444944-458579 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024058	protein coding gene	Chr2:498360-515373 (+)
WSB/EiJ	MGP_WSBEiJ_G0024577	protein coding gene	Chr2:488117-501941 (+)

Human Ortholog

CDNF, cerebral dopamine neurotrophic factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDNF, cerebral dopamine neurotrophic factor
Synonyms

ARMETL1
Links

HGNC:24913

NCBI Gene ID: 441549

neXtProt AC: NX_Q49AH0

UniProt: Q49AH0
Chr Location

10p13

MGI Vertebrate Homology

Cdnf stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDNF
Gene Tree

Cdnf

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Phenotype Summary

18 phenotypes from 3 alleles in 3 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit degeneration of enteric neurons, age-dependent enhanced amphetamine-induced hyperlocomotion, and altered dopamine neuronal function.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

780
Tissues

44
cDNA Data

6
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdnf

ZFIN cdnf

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS15654.1

Ensembl

ENSMUSG00000039496 (Evidence)
NCBI Gene

227526

			Length	Strain/Species	Flank
genomic	227526	NCBI Gene Model \| MGI Sequence Detail	13312	C57BL/6J	± kb
transcript	NM_177647	RefSeq \| MGI Sequence Detail	3013	C57BL/6
polypeptide	Q8CC36	UniProt \| EBI \| MGI Sequence Detail	187	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004301 cerebral dopamine neurotrophic factor

(term hierarchy)
InterPro Domains

IPR019345 ARMET, C-terminal

IPR045333 ARMET-like

IPR045332 ARMET, N-terminal

IPR036361 SAP domain superfamily

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All nucleic 8

cDNA 6

Primer pair 1

Other 1

Microarray probesets 1

Summaries

All 32

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 10
Earliest

J:306364 Lindholm P, et al., Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature. 2007 Jul 5;448(7149):73-7
Latest

J:343184 Matas-Navarro P, et al., Sex and age differences in mice models of effort-based decision-making and anergia in depression: the role of dopamine, and cerebral-dopamine-neurotrophic-factor. Psychopharmacology (Berl). 2023 Nov;240(11):2285-2302

TSS for Cdnf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15898	Chr2:3514072-3514111 (+)	-10 bp
Tssr15899	Chr2:3514129-3514164 (+)	45 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24