Rft1 MGI Mouse Gene Detail - MGI:3607791

Symbol

Rft1
Name

RFT1 homolog

Feature Type

protein coding gene
IDs

MGI:3607791
NCBI Gene: 328370
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:30376317-30413274 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 18.90 cM
Mapping Data

1 experiment

SNPs within 2kb

872 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3607791	protein coding gene	Chr14:30375041-30413274 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021106	protein coding gene	Chr14:23788863-23827842 (+)
A/J	MGP_AJ_G0021054	protein coding gene	Chr14:22906847-22944248 (+)
AKR/J	MGP_AKRJ_G0021031	protein coding gene	Chr14:24016061-24055387 (+)
BALB/cJ	MGP_BALBcJ_G0021058	protein coding gene	Chr14:23004914-23042429 (+)
C3H/HeJ	MGP_C3HHeJ_G0020841	protein coding gene	Chr14:23873381-23911721 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021490	protein coding gene	Chr14:24736206-24779956 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019053	protein coding gene	Chr14:22963734-23002582 (+)
CAST/EiJ	MGP_CASTEiJ_G0020366	protein coding gene	Chr14:23617040-23659100 (+)
CBA/J	MGP_CBAJ_G0020808	protein coding gene	Chr14:25690060-25731310 (+)
DBA/2J	MGP_DBA2J_G0020930	protein coding gene	Chr14:22939593-22976205 (+)
FVB/NJ	MGP_FVBNJ_G0020914	protein coding gene	Chr14:22893610-22930961 (+)
LP/J	MGP_LPJ_G0020999	protein coding gene	Chr14:24111919-24149778 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020940	protein coding gene	Chr14:24977941-25016403 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021523	protein coding gene	Chr14:23761801-23797750 (+)
PWK/PhJ	MGP_PWKPhJ_G0020114	protein coding gene	Chr14:22374000-22411695 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019938	protein coding gene	Chr14:23352492-23393238 (+)
WSB/EiJ	MGP_WSBEiJ_G0020421	protein coding gene	Chr14:23824496-23862407 (+)

Human Ortholog

RFT1, RFT1 homolog

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RFT1, RFT1 homolog
Synonyms

CDG1N
Links

HGNC:30220

NCBI Gene ID: 91869

neXtProt AC: NX_Q96AA3

UniProt: Q96AA3
Chr Location

3p21.1; chr3:53066853-53130453 (-) GRCh38

MGI Vertebrate Homology

Rft1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RFT1
Gene Tree

Rft1

Diseases

1 with human RFT1 associations

				Human Disease	Mouse Models
				congenital disorder of glycosylation In IDs congenital disorder of glycosylation In DOID:0080566 OMIM:612015 ORDO:244310

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

7
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

838
Tissues

120
cDNA Data

17
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rft1

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All Sequences

63
RefSeq

19
UniProt

4
CCDS

CCDS26896.1

Ensembl

ENSMUSG00000052395 (Evidence)
NCBI Gene

328370

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052395	Ensembl Gene Model \| MGI Sequence Detail	36958	C57BL/6J	± kb
transcript	ENSMUST00000064230	Ensembl \| MGI Sequence Detail	2387	Not Applicable
polypeptide	ENSMUSP00000064153	Ensembl \| MGI Sequence Detail	541	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013919 protein RFT1

(term hierarchy)
InterPro Domains

IPR007594 RFT1

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All nucleic 17

cDNA 17

Microarray probesets 1

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 11
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rft1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124846	Chr14:30376299-30376321 (+)	-7 bp
Tssr124847	Chr14:30376324-30376381 (+)	36 bp
Tssr124848	Chr14:30399230-30399235 (+)	22,916 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24