Tmem132b Gene Detail

Summary

• Symbol
  Tmem132b
• Name
  transmembrane protein 132B

• Feature Type
  protein coding gene
• IDs
  MGI:3609245
  NCBI Gene: 208151
• Alliance
  gene page
• Transcription Start Sites
  6 TSS

Location &
Maps

• Sequence Map
  Chr5:125609449-125869647 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 64.27 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  7442 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3609245	protein coding gene	Chr5:125608838-125869647 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030114	protein coding gene	Chr5:129392007-129654287 (+)
A/J	MGP_AJ_G0030081	protein coding gene	Chr5:123966060-124222249 (+)
AKR/J	MGP_AKRJ_G0030015	protein coding gene	Chr5:127994384-128258841 (+)
BALB/cJ	MGP_BALBcJ_G0030091	protein coding gene	Chr5:125300385-125561835 (+)
C3H/HeJ	MGP_C3HHeJ_G0029808	protein coding gene	Chr5:128597234-128860101 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030544	protein coding gene	Chr5:134396582-134671003 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027769	protein coding gene	Chr5:118498817-118753813 (+)
CAST/EiJ	MGP_CASTEiJ_G0029217	protein coding gene	Chr5:127740101-128004764 (+)
CBA/J	MGP_CBAJ_G0029778	protein coding gene	Chr5:139669972-139952277 (+)
DBA/2J	MGP_DBA2J_G0029928	protein coding gene	Chr5:123982101-124239222 (+)
FVB/NJ	MGP_FVBNJ_G0029884	protein coding gene	Chr5:123062943-123324973 (+)
LP/J	MGP_LPJ_G0030017	protein coding gene	Chr5:129906717-130179711 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029915	protein coding gene	Chr5:143173034-143436350 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030585	protein coding gene	Chr5:127605599-127873510 (+)
PWK/PhJ	MGP_PWKPhJ_G0028931	protein coding gene	Chr5:122821769-123084227 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028768	protein coding gene	Chr5:125246237-125512857 (+)
WSB/EiJ	MGP_WSBEiJ_G0029291	protein coding gene	Chr5:128308148-128570983 (+)

Homology

• Human Ortholog
  TMEM132B, transmembrane protein 132B

• Vertebrate Orthologs
  5

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TMEM132B, transmembrane protein 132B
  
• Links
  HGNC:29397

  NCBI Gene ID: 114795

  neXtProt AC: NX_Q14DG7

  UniProt: Q14DG7

  
  
• Chr Location
  12q24.31-q24.32; chr12:125186386-125662377 (+)  GRCh38

---

• MGI Vertebrate Homology
  Tmem132b stringent orthology
  1 human;1 mouse;1 rat;3 zebrafish
  
• HCOP
  vertebrate homology predictions: TMEM132B
• Gene Tree
  Tmem132b
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  12 phenotype references
  

• All Mutations and Alleles
  12
• Chemically induced (other)
  1
• Endonuclease-mediated
  3
• Gene trapped
  7
• Radiation induced
  1
• Genomic Mutations
  2 involving Tmem132b
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  48 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  715
• Tissues
  8
• cDNA Data
  13
• Literature Summary
  1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase tmem132b

Sequences &
Gene Models

• All Sequences
  31
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS57384.1

• Ensembl
  ENSMUSG00000070498 (Evidence)
• NCBI Gene
  208151

Representative Sequences			Length	Strain/Species
genomic	208151	NCBI Gene Model | MGI Sequence Detail	260199	C57BL/6J
transcript	NM_001190352	RefSeq | MGI Sequence Detail	7997	C57BL/6
polypeptide	NP_001177281	RefSeq | MGI Sequence Detail	1078	C57BL/6

Protein
Information

• UniProt
  3 Sequences
• InterPro Domains
  IPR026307 Transmembrane protein 132
  IPR031437 Transmembrane protein family 132, middle domain
  IPR031436 Transmembrane protein TMEM132, C-terminal
  IPR031435 Transmembrane protein TMEM132, N-terminal
• GlyGen
  F7BAB2 4 sites, 4 N-linked glycans (4 sites)

Molecular
Reagents

• All nucleic 15

  cDNA 13

  Primer pair 1

  Other 1

  
  

  Microarray probesets 3

References

• Summaries
  All 25

  Developmental Gene Expression 1

  Phenotypes 12
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:359132 Wang G, et al., The TMEM132B-GABA(A) receptor complex controls alcohol actions in the brain. Cell. 2024 Sep 27;

TSS for Tmem132b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48945	Chr5:125608851-125608883 (+)	-582 bp
Tssr48946	Chr5:125609441-125609457 (+)	0 bp
Tssr48947	Chr5:125609467-125609483 (+)	26 bp
Tssr1639	Chr5:125609595-125609602 (+)	150 bp
Tssr48948	Chr5:125609605-125609608 (+)	158 bp
Tssr48949	Chr5:125632501-125632503 (+)	23,053 bp