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Lingo3 Gene Detail
Summary
  • Symbol
    Lingo3
  • Name
    leucine rich repeat and Ig domain containing 3
  • Synonyms
    LERN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3609246
    NCBI Gene: 237403
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80668635-80679873 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3609246
 protein coding gene Chr10:80668635-80679873 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017523
 protein coding gene Chr10:81494839-81506071 (-)
A/J MGP_AJ_G0017501
 protein coding gene Chr10:78625044-78636275 (-)
AKR/J MGP_AKRJ_G0017462
 protein coding gene Chr10:80779864-80791096 (-)
BALB/cJ MGP_BALBcJ_G0017463
 protein coding gene Chr10:78841020-78852252 (-)
C3H/HeJ MGP_C3HHeJ_G0017286
 protein coding gene Chr10:80865566-80876798 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017917
 protein coding gene Chr10:84290821-84302053 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015606
 protein coding gene Chr10:74836237-74847427 (-)
CAST/EiJ MGP_CASTEiJ_G0016853
 protein coding gene Chr10:81098055-81109289 (-)
CBA/J MGP_CBAJ_G0017258
 protein coding gene Chr10:87567894-87579126 (-)
DBA/2J MGP_DBA2J_G0017364
 protein coding gene Chr10:77823405-77834637 (-)
FVB/NJ MGP_FVBNJ_G0017358
 protein coding gene Chr10:77054481-77065713 (-)
LP/J MGP_LPJ_G0017435
 protein coding gene Chr10:81954342-81965574 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017384
 protein coding gene Chr10:89479775-89491007 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017958
 protein coding gene Chr10:80776001-80787233 (-)
PWK/PhJ MGP_PWKPhJ_G0016634
 protein coding gene Chr10:77716278-77727568 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016424
 protein coding gene Chr10:79724202-79735424 (-)
WSB/EiJ MGP_WSBEiJ_G0016913
 protein coding gene Chr10:80810677-80821906 (-)



Homology
more
  • Human Ortholog
    LINGO3, leucine rich repeat and Ig domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LINGO3, leucine rich repeat and Ig domain containing 3
  • Synonyms
    LERN2, LRRN6B
  • Links
    NCBI Gene ID: 645191
    neXtProt AC: NX_P0C6S8
    UniProt: P0C6S8

  • Chr Location
    19p13.3; chr19:2287164-2308154 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    38
  • cDNA Data
    6
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 237403 NCBI Gene Model | MGI Sequence Detail 11239 C57BL/6J ±  kb
transcript NM_001359746 RefSeq | MGI Sequence Detail 3478 C57BL/6  
polypeptide Q6GQU6 UniProt | EBI | MGI Sequence Detail 589 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000030939 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3
    (term hierarchy)
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
    IPR050328 Multifunctional Developmental and Immune Receptor
  • GlyGen
    Q6GQU6 10 sites, 7 N-linked glycans (7 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 8
    cDNA 6
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:2143690
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory