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Chrna10 Gene Detail
Summary
  • Symbol
    Chrna10
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:3609260
    NCBI Gene: 504186
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101760473-101766035 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    218 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3609260
 protein coding gene Chr7:101760469-101766564 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032603
 protein coding gene Chr7:105142099-105147498 (-)
A/J MGP_AJ_G0032579
 protein coding gene Chr7:102462150-102469553 (-)
AKR/J MGP_AKRJ_G0032515
 protein coding gene Chr7:104913728-104919458 (-)
BALB/cJ MGP_BALBcJ_G0032590
 protein coding gene Chr7:102155388-102160775 (-)
C3H/HeJ MGP_C3HHeJ_G0032304
 protein coding gene Chr7:105301733-105312458 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033087
 protein coding gene Chr7:109106540-109111878 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030081
 protein coding gene Chr7:104816551-104821801 (-)
CAST/EiJ MGP_CASTEiJ_G0031630
 protein coding gene Chr7:96850003-96856905 (-)
CBA/J MGP_CBAJ_G0032270
 protein coding gene Chr7:112886846-112893435 (-)
DBA/2J MGP_DBA2J_G0032422
 protein coding gene Chr7:100787693-100793104 (-)
FVB/NJ MGP_FVBNJ_G0032378
 protein coding gene Chr7:100573360-100578729 (-)
LP/J MGP_LPJ_G0032511
 protein coding gene Chr7:106455928-106461315 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032412
 protein coding gene Chr7:114199096-114205370 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033109
 protein coding gene Chr7:104190042-104195487 (-)
PWK/PhJ MGP_PWKPhJ_G0031348
 protein coding gene Chr7:93906311-93912289 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031192
 protein coding gene Chr7:91482096-91501389 (-)
WSB/EiJ MGP_WSBEiJ_G0031747
 protein coding gene Chr7:104872731-104878167 (-)



Homology
more
  • Human Ortholog
    CHRNA10, cholinergic receptor nicotinic alpha 10 subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRNA10, cholinergic receptor nicotinic alpha 10 subunit
  • Links
    NCBI Gene ID: 57053
    neXtProt AC: NX_Q9GZZ6
    UniProt: Q9GZZ6

  • Chr Location
    11p15.4; chr11:3665587-3671384 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired synaptic function and integrity of the olivocochlear system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066279 Ensembl Gene Model | MGI Sequence Detail 5563 C57BL/6J ±  kb
    transcript ENSMUST00000084830 Ensembl | MGI Sequence Detail 2513 Not Applicable  
    polypeptide ENSMUSP00000081891 Ensembl | MGI Sequence Detail 447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 1
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 27
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:323894 Richter K, et al., Comparison of the Anti-inflammatory Properties of Two Nicotinic Acetylcholine Receptor Ligands, Phosphocholine and pCF3-diEPP. Front Cell Neurosci. 2022;16:779081
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory