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Rnf217 Gene Detail
Summary
  • Symbol
    Rnf217
  • Name
    ring finger protein 217
  • Synonyms
    Ibrdc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3610311
    NCBI Gene: 268291
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:31377883-31485721 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 17.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3081 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3610311
 protein coding gene Chr10:31369189-31485721 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017123
 protein coding gene Chr10:29722673-29842780 (-)
A/J MGP_AJ_G0017100
 protein coding gene Chr10:28850909-28968415 (-)
AKR/J MGP_AKRJ_G0017060
 protein coding gene Chr10:29316166-29432949 (-)
BALB/cJ MGP_BALBcJ_G0017063
 protein coding gene Chr10:28927705-29048862 (-)
C3H/HeJ MGP_C3HHeJ_G0016883
 protein coding gene Chr10:29589342-29714571 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017521
 protein coding gene Chr10:30627538-30752919 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015218
 protein coding gene Chr10:27237094-27355774 (-)
CAST/EiJ MGP_CASTEiJ_G0016462
 protein coding gene Chr10:29638613-29773069 (-)
CBA/J MGP_CBAJ_G0016857
 protein coding gene Chr10:32101980-32229044 (-)
DBA/2J MGP_DBA2J_G0016962
 protein coding gene Chr10:28539409-28666314 (-)
FVB/NJ MGP_FVBNJ_G0016957
 protein coding gene Chr10:28120857-28242560 (-)
LP/J MGP_LPJ_G0017039
 protein coding gene Chr10:29726499-29847049 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016987
 protein coding gene Chr10:32248035-32375496 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017557
 protein coding gene Chr10:29214864-29341382 (-)
PWK/PhJ MGP_PWKPhJ_G0016244
 protein coding gene Chr10:28300853-28421308 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016027
 protein coding gene Chr10:29160544-29287263 (-)
WSB/EiJ MGP_WSBEiJ_G0016525
 protein coding gene Chr10:29374353-29494927 (-)



Homology
more
  • Human Ortholog
    RNF217, ring finger protein 217
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF217, ring finger protein 217
  • Synonyms
    C6orf172, dJ84N20.1, IBRDC1, OSTL
  • Links
    NCBI Gene ID: 154214
    neXtProt AC: NX_Q8TC41
    UniProt: Q8TC41

  • Chr Location
    6q22.31; chr6:124962437-125092634 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Macrophage- and intestinal enterocyte-specific knock-out mice show abnormal iron metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    5
  • cDNA Data
    18
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 268291 NCBI Gene Model | MGI Sequence Detail 107839 C57BL/6J ±  kb
    transcript NM_001146349 RefSeq | MGI Sequence Detail 2873 C57BL/6  
    polypeptide D3YYI7 UniProt | EBI | MGI Sequence Detail 515 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • EC
      2.3.2.31
    • InterPro Domains
      IPR031127 E3 ubiquitin ligase RBR family
      IPR047551 E3 ubiquitin-protein ligase RNF217, BRcat domain
      IPR047552 E3 ubiquitin-protein ligase RNF217, Rcat domain
      IPR047550 E3 ubiquitin-protein ligase RNF217, variant RING finger, HC subclass
      IPR002867 IBR domain
      IPR044066 TRIAD supradomain
      IPR013083 Zinc finger, RING/FYVE/PHD-type
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143697, MGI:2143726
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory