Rbm24 MGI Mouse Gene Detail - MGI:3610364 - RNA binding motif protein 24

Symbol

Rbm24
Name

RNA binding motif protein 24
Synonyms

6330546B05Rik

Feature Type

protein coding gene
IDs

MGI:3610364
NCBI Gene: 666794
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr13:46571910-46584571 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 23.61 cM
Mapping Data

3 experiments

SNPs within 2kb

286 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3610364	protein coding gene	Chr13:46571664-46584575 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020512	protein coding gene	Chr13:45183412-45198587 (+)
A/J	MGP_AJ_G0020466	protein coding gene	Chr13:43616224-43630335 (+)
AKR/J	MGP_AKRJ_G0020443	protein coding gene	Chr13:44814807-44829382 (+)
BALB/cJ	MGP_BALBcJ_G0020462	protein coding gene	Chr13:43821136-43837290 (+)
C3H/HeJ	MGP_C3HHeJ_G0020261	protein coding gene	Chr13:44681525-44695193 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020895	protein coding gene	Chr13:46567725-46581162 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018481	protein coding gene	Chr13:41660059-41672603 (+)
CAST/EiJ	MGP_CASTEiJ_G0019776	protein coding gene	Chr13:44608091-44622190 (+)
CBA/J	MGP_CBAJ_G0020222	protein coding gene	Chr13:48508781-48523994 (+)
DBA/2J	MGP_DBA2J_G0020344	protein coding gene	Chr13:43177946-43192163 (+)
FVB/NJ	MGP_FVBNJ_G0020323	protein coding gene	Chr13:42697112-42710850 (+)
LP/J	MGP_LPJ_G0020419	protein coding gene	Chr13:45410522-45427126 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020352	protein coding gene	Chr13:48337188-48352922 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020938	protein coding gene	Chr13:44499370-44514362 (+)
PWK/PhJ	MGP_PWKPhJ_G0019532	protein coding gene	Chr13:43300232-43313551 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019360	protein coding gene	Chr13:43173921-43186958 (+)
WSB/EiJ	MGP_WSBEiJ_G0019838	protein coding gene	Chr13:44827964-44841473 (+)

Human Ortholog

RBM24, RNA binding motif protein 24

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBM24, RNA binding motif protein 24
Synonyms

dJ259A10.1, RNPC6
Links

HGNC:21539

NCBI Gene ID: 221662

neXtProt AC: NX_Q9BX46

UniProt: Q9BX46
Chr Location

6p22.3; chr6:17281361-17293871 (+) GRCh38

MGI Vertebrate Homology

Rbm24 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RBM24
Gene Tree

Rbm24

Diseases

1 with Rbm24 mouse models

Human Disease

Mouse Models

dilated cardiomyopathy

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

5
Genomic Mutations

1 involving Rbm24
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit lethality between E12.5 and E13.5 with embryonic growth retardation, thin and unfused atrioventricular cushions, reduced myocardial trabeculation and increased apoptosis in the heart.

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All GO Annotations

50
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

887
Tissues

84
cDNA Data

34
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rbm24

ZFIN rbm24a, rbm24b

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All Sequences

37
RefSeq

3
UniProt

1
CCDS

CCDS36651.1

Ensembl

ENSMUSG00000038132 (Evidence)
NCBI Gene

666794

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038132	Ensembl Gene Model \| MGI Sequence Detail	12662	C57BL/6J	± kb
transcript	ENSMUST00000037923	Ensembl \| MGI Sequence Detail	3086	Not Applicable
polypeptide	ENSMUSP00000043120	Ensembl \| MGI Sequence Detail	236	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013789 RNA-binding protein 24

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR050886 RNA-binding_regulatory_proteins

IPR000504 RNA recognition motif domain

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All nucleic 40

cDNA 34

Primer pair 3

Other 3

Microarray probesets 7

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MGI:1923426, MGI:2145271

Summaries

All 46

Developmental Gene Expression 11

Diseases 1

Gene Ontology 10

Phenotypes 11
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:353076 Wang K, et al., Rbm24/Notch1 signaling regulates adult neurogenesis in the subventricular zone and mediates Parkinson-associated olfactory dysfunction. Theranostics. 2024;14(11):4499-4518

TSS for Rbm24:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119589	Chr13:46571688-46571714 (+)	-209 bp
Tssr119590	Chr13:46571742-46571792 (+)	-143 bp
Tssr119591	Chr13:46571944-46571986 (+)	55 bp
Tssr119592	Chr13:46572496-46572513 (+)	595 bp
Tssr119593	Chr13:46573613-46573617 (+)	1,705 bp
Tssr119594	Chr13:46574006-46574017 (+)	2,102 bp
Tssr119595	Chr13:46583098-46583109 (+)	11,194 bp
Tssr119596	Chr13:46584161-46584165 (+)	12,253 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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