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Tox2 Gene Detail
Summary
  • Symbol
    Tox2
  • Name
    TOX high mobility group box family member 2
  • Synonyms
    LOC269389, RxHMG1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3611233
    NCBI Gene: 269389
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:163045047-163166092 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3870 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3611233
 protein coding gene Chr2:163045045-163166092 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026819
 protein coding gene Chr2:168525571-168655913 (+)
A/J MGP_AJ_G0026785
 protein coding gene Chr2:161745126-161867701 (+)
AKR/J MGP_AKRJ_G0026756
 protein coding gene Chr2:166525398-166650013 (+)
BALB/cJ MGP_BALBcJ_G0026794
 protein coding gene Chr2:162072506-162195712 (+)
C3H/HeJ MGP_C3HHeJ_G0026536
 protein coding gene Chr2:166866800-166993334 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027242
 protein coding gene Chr2:173458532-173592204 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024612
 protein coding gene Chr2:155034110-155154891 (+)
CAST/EiJ MGP_CASTEiJ_G0025997
 protein coding gene Chr2:167240885-167374425 (+)
CBA/J MGP_CBAJ_G0026513
 protein coding gene Chr2:179752371-179878188 (+)
DBA/2J MGP_DBA2J_G0026651
 protein coding gene Chr2:160912434-161035161 (+)
FVB/NJ MGP_FVBNJ_G0026617
 protein coding gene Chr2:159286464-159410492 (+)
LP/J MGP_LPJ_G0026754
 protein coding gene Chr2:168664664-168794936 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026639
 protein coding gene Chr2:183404854-183532846 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027298
 protein coding gene Chr2:166414361-166538746 (+)
PWK/PhJ MGP_PWKPhJ_G0025731
 protein coding gene Chr2:160467713-160590768 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025534
 protein coding gene Chr2:165276564-165409796 (+)
WSB/EiJ MGP_WSBEiJ_G0026067
 protein coding gene Chr2:167272363-167398873 (+)



Homology
more
  • Human Ortholog
    TOX2, TOX high mobility group box family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOX2, TOX high mobility group box family member 2
  • Synonyms
    C20orf100, dJ1108D11.2, dJ495O3.1, GCX-1, GCX1
  • Links
    NCBI Gene ID: 84969
    neXtProt AC: NX_Q96NM4
    UniProt: Q96NM4

  • Chr Location
    20q13.12; chr20:43914852-44069616 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show defective/reduced T follicular helper cell differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    38
  • cDNA Data
    3
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269389 NCBI Gene Model | MGI Sequence Detail 121046 C57BL/6J ±  kb
    transcript NM_001372579 RefSeq | MGI Sequence Detail 3669 C57BL/6  
    polypeptide NP_001359507 RefSeq | MGI Sequence Detail 541 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
      IPR051365 TOX high mobility group box domain-containing protein
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 4
      Primer pair 1
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2139084, MGI:2139242
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 5
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory