Bin2 MGI Mouse Gene Detail - MGI:3611448

Symbol

Bin2
Name

bridging integrator 2

Feature Type

protein coding gene
IDs

MGI:3611448
NCBI Gene: 668218
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr15:100538963-100567384 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.37 cM
Mapping Data

1 experiment

SNPs within 2kb

840 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3611448	protein coding gene	Chr15:100538958-100567434 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022358	protein coding gene	Chr15:102625572-102653899 (-)
A/J	MGP_AJ_G0022320	protein coding gene	Chr15:98581651-98609586 (-)
AKR/J	MGP_AKRJ_G0022296	protein coding gene	Chr15:101592912-101620981 (-)
BALB/cJ	MGP_BALBcJ_G0022324	protein coding gene	Chr15:98691784-98719949 (-)
C3H/HeJ	MGP_C3HHeJ_G0022094	protein coding gene	Chr15:101675180-101702170 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022772	protein coding gene	Chr15:106479843-106509218 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020297	protein coding gene	Chr15:94333106-94359023 (-)
CAST/EiJ	MGP_CASTEiJ_G0021619	protein coding gene	Chr15:102524685-102552417 (-)
CBA/J	MGP_CBAJ_G0022063	protein coding gene	Chr15:110120857-110151010 (-)
DBA/2J	MGP_DBA2J_G0022190	protein coding gene	Chr15:97932151-97960688 (-)
FVB/NJ	MGP_FVBNJ_G0022169	protein coding gene	Chr15:96956248-96983026 (-)
LP/J	MGP_LPJ_G0022261	protein coding gene	Chr15:102780130-102807758 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022190	protein coding gene	Chr15:113852749-113882835 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022786	protein coding gene	Chr15:101594032-101620947 (-)
PWK/PhJ	MGP_PWKPhJ_G0021358	protein coding gene	Chr15:98065069-98093557 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021190	protein coding gene	Chr15:101484771-101513986 (-)
WSB/EiJ	MGP_WSBEiJ_G0021669	protein coding gene	Chr15:102219227-102247175 (-)

Human Ortholog

BIN2, bridging integrator 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BIN2, bridging integrator 2
Synonyms

BRAP-1
Links

HGNC:1053

NCBI Gene ID: 51411

neXtProt AC: NX_Q9UBW5

UniProt: Q9UBW5
Chr Location

12q13.13; chr12:51281038-51324668 (-) GRCh38

MGI Vertebrate Homology

Bin2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BIN2
Gene Tree

Bin2

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References

1 with disease annotations

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Bin2
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for a knock-out allele are viable, fertile and healthy with no significant alterations in basic blood parameters.

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All GO Annotations

24
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

2
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bin2

ZFIN bin2b

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All Sequences

56
RefSeq

6
UniProt

7
CCDS

CCDS59622.1

Ensembl

ENSMUSG00000098112 (Evidence)
NCBI Gene

668218

			Length	Strain/Species	Flank
genomic	668218	NCBI Gene Model \| MGI Sequence Detail	28422	C57BL/6J	± kb
transcript	NM_001270537	RefSeq \| MGI Sequence Detail	1981	C57BL/6
polypeptide	D3Z6Q9	UniProt \| EBI \| MGI Sequence Detail	489	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000004749 bridging integrator 2

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR003005 Amphiphysin

IPR004148 BAR domain

IPR048886 Bridging integrator 2, C-terminal tail

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All nucleic 9

cDNA 9

Summaries

All 42

Developmental Gene Expression 1

Diseases 1

Gene Ontology 5

Phenotypes 24
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bin2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136460	Chr15:100567416-100567441 (-)	-45 bp
Tssr136459	Chr15:100567393-100567410 (-)	-18 bp
Tssr136458	Chr15:100567377-100567392 (-)	-1 bp
Tssr136457	Chr15:100565485-100565486 (-)	1,898 bp
Tssr136456	Chr15:100542905-100542916 (-)	24,473 bp
Tssr136455	Chr15:100542821-100542838 (-)	24,554 bp
Tssr136454	Chr15:100542793-100542819 (-)	24,578 bp
Tssr136453	Chr15:100539392-100539402 (-)	27,987 bp
Tssr136452	Chr15:100539340-100539363 (-)	28,032 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24