Kcnmb3 MGI Mouse Gene Detail - MGI:3612244 - potassium large conductance calcium-activated channel, subfamily M, beta member 3

Symbol

Kcnmb3
Name

potassium large conductance calcium-activated channel, subfamily M, beta member 3
Synonyms

Gm5707

Feature Type

protein coding gene
IDs

MGI:3612244
NCBI Gene: 100502876
Alliance

gene page

Sequence Map

Chr3:32525737-32546380 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 15.73 cM
Mapping Data

2 experiments

SNPs within 2kb

776 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3612244	protein coding gene	Chr3:32518995-32557045 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027137	protein coding gene	Chr3:30075620-30102399 (-)
A/J	MGP_AJ_G0027097	protein coding gene	Chr3:29652117-29673103 (-)
AKR/J	MGP_AKRJ_G0027066	protein coding gene	Chr3:30111565-30135208 (-)
BALB/cJ	MGP_BALBcJ_G0027109	protein coding gene	Chr3:29306675-29326321 (-)
C3H/HeJ	MGP_C3HHeJ_G0026852	protein coding gene	Chr3:30136485-30156718 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027555	protein coding gene	Chr3:31576281-31599421 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024916	protein coding gene	Chr3:27486190-27506695 (-)
CAST/EiJ	MGP_CASTEiJ_G0026305	protein coding gene	Chr3:29997919-30024198 (-)
CBA/J	MGP_CBAJ_G0026829	protein coding gene	Chr3:32412829-32438876 (-)
DBA/2J	MGP_DBA2J_G0026963	protein coding gene	Chr3:29124276-29145076 (-)
FVB/NJ	MGP_FVBNJ_G0026931	protein coding gene	Chr3:28585659-28606411 (-)
LP/J	MGP_LPJ_G0027075	protein coding gene	Chr3:30844676-30865762 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026951	protein coding gene	Chr3:34934243-34954482 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027614	protein coding gene	Chr3:29908159-29926133 (-)
PWK/PhJ	MGP_PWKPhJ_G0026038	protein coding gene	Chr3:28668135-28688588 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025850	protein coding gene	Chr3:29310822-29332677 (-)
WSB/EiJ	MGP_WSBEiJ_G0026379	protein coding gene	Chr3:29915585-29937659 (-)

Human Ortholog

KCNMB3, potassium calcium-activated channel subfamily M regulatory beta subunit 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNMB3, potassium calcium-activated channel subfamily M regulatory beta subunit 3
Synonyms

BKBETA3, HBETA3, KCNMB2, KCNMBL, K(VCA)BETA-3, SLO-BETA-3, SLOBETA3
Links

HGNC:6287

NCBI Gene ID: 27094

neXtProt AC: NX_Q9NPA1

UniProt: Q9NPA1
Chr Location

3q26.32; chr3:179236691-179267050 (-) GRCh38

MGI Vertebrate Homology

Kcnmb3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KCNMB3
Gene Tree

Kcnmb3

less

References

1 with disease annotations

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

1 involving Kcnmb3
Find Mice (IMSR)

12 strains or lines available

less

All GO Annotations

11
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kcnmb3

ZFIN kcnmb3

less

All Sequences

30
RefSeq

6
UniProt

1
CCDS

CCDS57206.1

Ensembl

ENSMUSG00000091091 (Evidence)
NCBI Gene

100502876

			Length	Strain/Species	Flank
genomic	ENSMUSG00000091091	Ensembl Gene Model \| MGI Sequence Detail	20644	C57BL/6J	± kb
transcript	ENSMUST00000164954	Ensembl \| MGI Sequence Detail	1715	Not Applicable
polypeptide	ENSMUSP00000130177	Ensembl \| MGI Sequence Detail	239	Not Applicable

less

UniProt

1 Sequence
InterPro Domains

IPR003930 Potassium channel, calcium-activated, BK, beta subunit

less

All nucleic 1

cDNA 1

less

MGI:3647479

Summaries

All 19

Diseases 1

Gene Ontology 2

Phenotypes 7
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24