Limk2 MGI Mouse Gene Detail - MGI:1197517

Symbol

Limk2
Name

LIM domain kinase 2
Synonyms

A930024P04Rik, Limk2a, Limk2b, LIM kinase 2, whe

Feature Type

protein coding gene
IDs

MGI:1197517
NCBI Gene: 16886
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:3294256-3359189 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 2.34 cM
Mapping Data

5 experiments

SNPs within 2kb

1471 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1197517	protein coding gene	Chr11:3293297-3359238 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017956	protein coding gene	Chr11:196607-265571 (-)
A/J	MGP_AJ_G0017929	protein coding gene	Chr11:257902-323229 (-)
AKR/J	MGP_AKRJ_G0017893	protein coding gene	Chr11:266492-335988 (-)
BALB/cJ	MGP_BALBcJ_G0017897	protein coding gene	Chr11:229925-294687 (-)
C3H/HeJ	MGP_C3HHeJ_G0017710	protein coding gene	Chr11:207706-275325 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018350	protein coding gene	Chr11:265631-331595 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016009	protein coding gene	Chr11:174819-240771 (-)
CAST/EiJ	MGP_CASTEiJ_G0017272	protein coding gene	Chr11:156337-225136 (-)
CBA/J	MGP_CBAJ_G0017685	protein coding gene	Chr11:430236-501628 (-)
DBA/2J	MGP_DBA2J_G0017796	protein coding gene	Chr11:179296-244049 (-)
FVB/NJ	MGP_FVBNJ_G0017787	protein coding gene	Chr11:206001-271085 (-)
LP/J	MGP_LPJ_G0017866	protein coding gene	Chr11:302680-371970 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017813	protein coding gene	Chr11:186064-256926 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018389	protein coding gene	Chr11:271679-341699 (-)
PWK/PhJ	MGP_PWKPhJ_G0017052	protein coding gene	Chr11:154574-221279 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016848	protein coding gene	Chr11:233033-302083 (-)
WSB/EiJ	MGP_WSBEiJ_G0017326	protein coding gene	Chr11:151539-220136 (-)

Human Ortholog

LIMK2, LIM domain kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LIMK2, LIM domain kinase 2
Links

HGNC:6614

NCBI Gene ID: 3985

neXtProt AC: NX_P53671

UniProt: P53671
Chr Location

22q12.2; chr22:31212239-31280080 (+) GRCh38

MGI Vertebrate Homology

Limk2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LIMK2
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Limk2

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Phenotype Summary

28 phenotypes from 4 alleles in 4 genetic backgrounds
2 images
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

95
Endonuclease-mediated

2
Gene trapped

89
Spontaneous

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

78 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male homozygotes for targeted null mutations exhibit small testes but are fertile. Mutant kidneys have fewer glomeruli and dilated renal tubules, but function normally. Mice homozygous for a gene trap allele or spontaneous mutation have open eyelids at birth, corneal abnormalities and inflammation.

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All GO Annotations

57
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1036
Tissues

135
cDNA Data

24
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase limk2

ZFIN limk2

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All Sequences

110
RefSeq

28
UniProt

4
CCDS

CCDS24358.1, CCDS24359.1, CCDS24360.1, CCDS88122.1

Ensembl

ENSMUSG00000020451 (Evidence)
NCBI Gene

16886

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020451	Ensembl Gene Model \| MGI Sequence Detail	64934	C57BL/6J	± kb
transcript	ENSMUST00000101638	Ensembl \| MGI Sequence Detail	3514	Not Applicable
polypeptide	ENSMUSP00000099162	Ensembl \| MGI Sequence Detail	638	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009817 LIM domain kinase 2

(term hierarchy)
PDB

2YUB
EC

2.7.11.1
InterPro Domains

IPR050940 Actin-regulating Serine/Threonine Kinase

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR001781 Zinc finger, LIM-type

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All nucleic 37

Genomic 7

cDNA 25

Primer pair 4

Other 1

Microarray probesets 6

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MGI:2144678, MGI:2443338, MGI:3612834

Summaries

All 74

Developmental Gene Expression 19

Gene Ontology 12

Phenotypes 23
Earliest

J:44929 Koshimizu U, et al., cDNA cloning, genomic organization, and chromosomal localization of the mouse LIM motif-containing kinase gene, Limk2. Biochem Biophys Res Commun. 1997 Dec 18;241(2):243-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Limk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106470	Chr11:3359162-3359195 (-)	10 bp
Tssr106469	Chr11:3359116-3359159 (-)	51 bp
Tssr106468	Chr11:3359079-3359088 (-)	105 bp
Tssr3408	Chr11:3343366-3343369 (-)	15,821 bp
Tssr106467	Chr11:3321307-3321409 (-)	37,831 bp
Tssr106466	Chr11:3321282-3321293 (-)	37,901 bp
Tssr3407	Chr11:3303380-3303383 (-)	55,807 bp
Tssr106464	Chr11:3298681-3298696 (-)	60,500 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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