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Kncn Gene Detail
Summary
  • Symbol
    Kncn
  • Name
    kinocilin
  • Synonyms
    Kino, L5
  • Feature Type
    protein coding gene
  • IDs
    MGI:3614952
    NCBI Gene: 654462
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:115741597-115745079 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3614952
 protein coding gene Chr4:115741597-115746723 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028611
 protein coding gene Chr4:116728688-116733817 (+)
A/J MGP_AJ_G0028572
 protein coding gene Chr4:112274513-112279623 (+)
AKR/J MGP_AKRJ_G0028521
 protein coding gene Chr4:114680930-114686059 (+)
BALB/cJ MGP_BALBcJ_G0028593
 protein coding gene Chr4:112902936-112908052 (+)
C3H/HeJ MGP_C3HHeJ_G0028307
 protein coding gene Chr4:116260182-116265289 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029034
 protein coding gene Chr4:121253167-121258284 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026318
 protein coding gene Chr4:106320979-106326003 (+)
CAST/EiJ MGP_CASTEiJ_G0027741
 protein coding gene Chr4:113467709-113472837 (+)
CBA/J MGP_CBAJ_G0028274
 protein coding gene Chr4:124546514-124551627 (+)
DBA/2J MGP_DBA2J_G0028422
 protein coding gene Chr4:112923722-112928831 (+)
FVB/NJ MGP_FVBNJ_G0028390
 protein coding gene Chr4:111409877-111414989 (+)
LP/J MGP_LPJ_G0028524
 protein coding gene Chr4:116945972-116951101 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028417
 protein coding gene Chr4:129565732-129570834 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029071
 protein coding gene Chr4:115838492-115843621 (+)
PWK/PhJ MGP_PWKPhJ_G0027467
 protein coding gene Chr4:109682501-109687628 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027290
 protein coding gene Chr4:112083019-112088051 (+)
WSB/EiJ MGP_WSBEiJ_G0027820
 protein coding gene Chr4:115704529-115709647 (+)



Homology
more
  • Human Ortholog
    KNCN, kinocilin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KNCN, kinocilin
  • Synonyms
    Kino, L5
  • Links
    NCBI Gene ID: 148930
    neXtProt AC: NX_A6PVL3
    UniProt: A6PVL3

  • Chr Location
    1p33; chr1:46545641-46551647 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Kncn
  • Find Mice (IMSR)
    7 strains or lines available
Mice homozygous for a null allele exhibit normal hearing, hair bundle structure and mechanotransduction in cochlear outer hair cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    24
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 654462 NCBI Gene Model | MGI Sequence Detail 3483 C57BL/6J ±  kb
transcript NM_001320545 RefSeq | MGI Sequence Detail 899 C57BL/6  
polypeptide Q307W7 UniProt | EBI | MGI Sequence Detail 124 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 3
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 23
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:280115 Hu Q, et al., Deletion of Kncn Does Not Affect Kinocilium and Stereocilia Bundle Morphogenesis and Mechanotransduction in Cochlear Hair Cells. Front Mol Neurosci. 2018;11:326
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory