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Hoxd Complex/Cluster/Region Detail
Summary
  • Symbol
    Hoxd
  • Name
    homeobox D cluster
  • Synonyms
    Del1Ddu, Hox-4, Hox-5
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:96200
    NCBI Gene: 111337
  • Cluster Members
    Hoxd13, Hoxd12, Hoxd11 ... (9 members)
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 2, Syntenic
  • Mapping Data
    29 experiments
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 9 alleles in 6 genetic backgrounds
    28 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in multiple members of the cluster display a range of phenotypes including prenatal and postnatal lethality and developmental defects in the skeletal, reproductive and renal/urinary systems.
Sequences &
Gene Models
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Molecular
Reagents
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  • All nucleic 6
    Genomic 6
Other
Accession IDs
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MGD-MRK-10847, MGD-MRK-10857, MGD-MRK-10901, MGD-MRK-15348, MGI:3616017, MGI:98901
References
more
  • Summaries
    All 91
    Phenotypes 38
  • Earliest
    J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
  • Latest
    J:309510 Beccari L, et al., Dbx2 regulation in limbs suggests interTAD sharing of enhancers. Dev Dyn. 2021 Sep;250(9):1280-1299
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory