Hoxd Complex/Cluster/Region Detail

Summary

• Symbol
  Hoxd
• Name
  homeobox D cluster
• Synonyms
  Del1Ddu, Hox-4, Hox-5

• Feature Type
  complex/cluster/region
• IDs
  MGI:96200
  NCBI Gene: 111337
• Cluster Members
  Hoxd13, Hoxd12, Hoxd11 ... (9 members)
• Regulated by
  Rr44604, Rr44605, Rr44606 ... (7 regulatory regions)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 2, Syntenic
• Mapping Data
  29 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  23 phenotypes from 9 alleles in 6 genetic backgrounds
  28 phenotypes from multigenic genotypes
  39 phenotype references
  

• All Mutations and Alleles
  18
• Targeted
  18
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for mutations in multiple members of the cluster display a range of phenotypes including prenatal and postnatal lethality and developmental defects in the skeletal, reproductive and renal/urinary systems.

Sequences &
Gene Models

• NCBI Gene
  111337

Molecular
Reagents

• All nucleic 6

  Genomic 6

Other
Accession IDs

MGD-MRK-10847, MGD-MRK-10857, MGD-MRK-10901, MGD-MRK-15348, MGI:3616017, MGI:98901

References

• Summaries
  All 92

  Phenotypes 39
• Earliest
  J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
• Latest
  J:363560 Imai F, et al., HoxD transcription factors define monosynaptic sensory-motor specificity in the developing spinal cord. Development. 2021 Jun 15;148(12)

Hoxd expression regulated by:

Feature	Feature Type	Location	Reference
Rr44604, regulatory region 44604	CTCF binding site	Chr2:74516601-74517200	J:319862
Rr44605, regulatory region 44605	CTCF binding site	Chr2:74522001-74522400	J:319862
Rr44606, regulatory region 44606	CTCF binding site	Chr2:74524401-74524800	J:319862
Rr44607, regulatory region 44607	CTCF binding site	Chr2:74532401-74533000	J:319862
Rr44608, regulatory region 44608	CTCF binding site	Chr2:74546001-74546200	J:319862
Rr566, regulatory region 566	enhancer	Chr2, Syntenic	J:83372
Rr581, regulatory region 581	response element	Chr2, Syntenic	J:208763

Hoxd Cluster contains:

More Data for these features

Member	Feature Type	Location
Hoxd13, homeobox D13	protein coding gene	Chr2:74498654-74501943 (+)
Hoxd12, homeobox D12	protein coding gene	Chr2:74505357-74508049 (+)
Hoxd11, homeobox D11	protein coding gene	Chr2:74509902-74517360 (+)
Hoxd10, homeobox D10	protein coding gene	Chr2:74522268-74525449 (+)
Hoxd9, homeobox D9	protein coding gene	Chr2:74528107-74530552 (+)
Hoxd8, homeobox D8	protein coding gene	Chr2:74534973-74538277 (+)
Hoxd3, homeobox D3	protein coding gene	Chr2:74542337-74578615 (+)
Hoxd4, homeobox D4	protein coding gene	Chr2:74552322-74559504 (+)
Hoxd1, homeobox D1	protein coding gene	Chr2:74593324-74595486 (+)