Hoxd Complex/Cluster/Region Detail

Summary

• Symbol
  Hoxd
• Name
  homeobox D cluster
• Synonyms
  Del1Ddu, Hox-4, Hox-5

• Feature Type
  complex/cluster/region
• IDs
  MGI:96200
  NCBI Gene: 111337
• Cluster Members
  Hoxd13, Hoxd12, Hoxd11 ... (9 members)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 2, Syntenic
• Mapping Data
  29 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  23 phenotypes from 9 alleles in 6 genetic backgrounds
  28 phenotypes from multigenic genotypes
  38 phenotype references
  

• All Mutations and Alleles
  18
• Targeted
  18
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for mutations in multiple members of the cluster display a range of phenotypes including prenatal and postnatal lethality and developmental defects in the skeletal, reproductive and renal/urinary systems.

Sequences &
Gene Models

• NCBI Gene
  111337

Molecular
Reagents

• All nucleic 6

  Genomic 6

Other
Accession IDs

MGD-MRK-10847, MGD-MRK-10857, MGD-MRK-10901, MGD-MRK-15348, MGI:3616017, MGI:98901

References

• Summaries
  All 91

  Phenotypes 38
• Earliest
  J:8920 Lonai P, et al., New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA. 1987 Oct;6(5):409-18
• Latest
  J:309510 Beccari L, et al., Dbx2 regulation in limbs suggests interTAD sharing of enhancers. Dev Dyn. 2021 Sep;250(9):1280-1299

Hoxd Cluster contains:

More Data for these features

Member	Feature Type	Location
Hoxd13, homeobox D13	protein coding gene	Chr2:74498654-74501943 (+)
Hoxd12, homeobox D12	protein coding gene	Chr2:74505357-74508049 (+)
Hoxd11, homeobox D11	protein coding gene	Chr2:74509902-74517360 (+)
Hoxd10, homeobox D10	protein coding gene	Chr2:74522268-74525449 (+)
Hoxd9, homeobox D9	protein coding gene	Chr2:74528107-74530552 (+)
Hoxd8, homeobox D8	protein coding gene	Chr2:74534973-74538277 (+)
Hoxd3, homeobox D3	protein coding gene	Chr2:74542337-74578615 (+)
Hoxd4, homeobox D4	protein coding gene	Chr2:74552322-74559504 (+)
Hoxd1, homeobox D1	protein coding gene	Chr2:74593324-74595486 (+)

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