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Mir34c Gene Detail
Summary
  • Symbol
    Mir34c
  • Name
    microRNA 34c
  • Synonyms
    mir 34c, Mirn34c, mmu-mir-34c
Location &
Maps
more
  • Sequence Map
    Chr9:51014334-51014410 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 27.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3619365
 miRNA gene Chr9:51014334-51014410 (-)
129S1/SvImJ MGP_129S1SvImJ_G0009202
 miRNA gene Chr9:50018421-50018497 (-)
A/J MGP_AJ_G0009183
 miRNA gene Chr9:48498537-48498613 (-)
AKR/J MGP_AKRJ_G0009172
 miRNA gene Chr9:49508255-49508331 (-)
BALB/cJ MGP_BALBcJ_G0009168
 miRNA gene Chr9:48248585-48248661 (-)
C3H/HeJ MGP_C3HHeJ_G0009108
 miRNA gene Chr9:50003547-50003623 (-)
C57BL/6NJ MGP_C57BL6NJ_G0009410
 miRNA gene Chr9:51416853-51416929 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0008267
 miRNA gene Chr9:47956917-47956993 (-)
CAST/EiJ MGP_CASTEiJ_G0008940
 miRNA gene Chr9:49943756-49943832 (-)
CBA/J MGP_CBAJ_G0009075
 miRNA gene Chr9:53236050-53236126 (-)
DBA/2J MGP_DBA2J_G0009106
 miRNA gene Chr9:48356002-48356078 (-)
FVB/NJ MGP_FVBNJ_G0009123
 miRNA gene Chr9:47572020-47572096 (-)
LP/J MGP_LPJ_G0009200
 miRNA gene Chr9:50385828-50385904 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0009089
 miRNA gene Chr9:54815104-54815180 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0009379
 miRNA gene Chr9:49497843-49497919 (-)
PWK/PhJ MGP_PWKPhJ_G0008865
 miRNA gene Chr9:48330348-48330424 (-)
SPRET/EiJ MGP_SPRETEiJ_G0008705
 miRNA gene Chr9:49795836-49795912 (-)
WSB/EiJ MGP_WSBEiJ_G0009035
 miRNA gene Chr9:49507382-49507458 (-)



Homology
more
  • Human Ortholog
    MIR34C, microRNA 34c
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR34C, microRNA 34c
  • Synonyms
    mir-34c, MIRN34C, miRNA34C
  • Links
    NCBI Gene ID: 407042

  • Chr Location
    chr11:111513439-111513515 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    2 images
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele of Mir34b and Mir34c exhibit increased reprogramming efficiency of mouse embryonic fibroblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    29
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      23
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 723932 NCBI Gene Model | MGI Sequence Detail 77 C57BL/6J ±  kb
    transcript NR_029654 RefSeq | MGI Sequence Detail 77 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 8
      Primer pair 5
      Other 3
    Other Database
    Links
    less
    miRBase MI0000403
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 16
      Gene Ontology 8
      Phenotypes 1
    • Earliest
      J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
    • Latest
      J:317408 Grad M, et al., Altered White Matter and microRNA Expression in a Murine Model Related to Williams Syndrome Suggests That miR-34b/c Affects Brain Development via Ptpru and Dcx Modulation. Cells. 2022 Jan 4;11(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory