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Mir375 Gene Detail
Summary
  • Symbol
    Mir375
  • Name
    microRNA 375
  • Synonyms
    mir 375, Mirn375, mmu-mir-375
  • Feature Type
    miRNA gene
  • IDs
    MGI:3619376
    NCBI Gene: 723900
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74939817-74939880 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3619376
 miRNA gene Chr1:74939817-74939880 (-)
129S1/SvImJ MGP_129S1SvImJ_G0007631
 miRNA gene Chr1:75514078-75514141 (-)
A/J MGP_AJ_G0007626
 miRNA gene Chr1:72884518-72884581 (-)
AKR/J MGP_AKRJ_G0007600
 miRNA gene Chr1:74899745-74899808 (-)
BALB/cJ MGP_BALBcJ_G0007603
 miRNA gene Chr1:72944576-72944639 (-)
C3H/HeJ MGP_C3HHeJ_G0007549
 miRNA gene Chr1:75242681-75242744 (-)
C57BL/6NJ MGP_C57BL6NJ_G0007778
 miRNA gene Chr1:78458396-78458459 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0006948
 miRNA gene Chr1:68446595-68446658 (-)
CAST/EiJ MGP_CASTEiJ_G0007448
 miRNA gene Chr1:74567458-74567521 (-)
CBA/J MGP_CBAJ_G0007524
 miRNA gene Chr1:81014771-81014834 (-)
DBA/2J MGP_DBA2J_G0007558
 miRNA gene Chr1:72201326-72201389 (-)
FVB/NJ MGP_FVBNJ_G0007572
 miRNA gene Chr1:71399620-71399683 (-)
LP/J MGP_LPJ_G0007637
 miRNA gene Chr1:76635987-76636050 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0007546
 miRNA gene Chr1:84389608-84389671 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0007778
 miRNA gene Chr1:74973266-74973329 (-)
PWK/PhJ MGP_PWKPhJ_G0007381
 miRNA gene Chr1:71665336-71665399 (-)
SPRET/EiJ MGP_SPRETEiJ_G0007284
 miRNA gene Chr1:74338523-74338586 (-)
WSB/EiJ MGP_WSBEiJ_G0007513
 miRNA gene Chr1:74791172-74791235 (-)



Homology
more
  • Human Ortholog
    MIR375, microRNA 375
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR375, microRNA 375
  • Synonyms
    hsa-mir-375, mir-375, MIRN375, miRNA375
  • Links
    NCBI Gene ID: 494324

  • Chr Location
    chr2:219001645-219001708 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display hyperglycemia, hyperglucagonemia, decreased beta cell numnber and mass, increased alpha cell number, increased insulin and glucagon secretion, and enhanced gluconeogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    16
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      23
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 723900 NCBI Gene Model | MGI Sequence Detail 64 C57BL/6J ±  kb
    transcript NR_029876 RefSeq | MGI Sequence Detail 64 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 4
      Primer pair 1
      Other 3
    Other Database
    Links
    less
    miRBase MI0000792
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 11
      Gene Ontology 1
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:342036 Hung YH, et al., Integrative genome-scale analyses reveal post-transcriptional signatures of early human small intestinal development in a directed differentiation organoid model. BMC Genomics. 2023 Oct 26;24(1):641
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory