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Mir425 Gene Detail
Summary
  • Symbol
    Mir425
  • Name
    microRNA 425
  • Synonyms
    mir 425, Mirn425, mmu-mir-425
  • Feature Type
    miRNA gene
  • IDs
    MGI:3619401
    NCBI Gene: 723864
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr9:108445976-108446060 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3619401
 miRNA gene Chr9:108445976-108446060 (+)
129S1/SvImJ MGP_129S1SvImJ_G0009237
 miRNA gene Chr9:110536143-110536227 (+)
A/J MGP_AJ_G0009218
 miRNA gene Chr9:106485010-106485094 (+)
AKR/J MGP_AKRJ_G0009207
 miRNA gene Chr9:109154104-109154188 (+)
BALB/cJ MGP_BALBcJ_G0009202
 miRNA gene Chr9:106180474-106180558 (+)
C3H/HeJ MGP_C3HHeJ_G0009143
 miRNA gene Chr9:109555452-109555536 (+)
C57BL/6NJ MGP_C57BL6NJ_G0009444
 miRNA gene Chr9:113550826-113550910 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0008298
 miRNA gene Chr9:103913145-103913229 (+)
CAST/EiJ MGP_CASTEiJ_G0008973
 miRNA gene Chr9:109513428-109513512 (+)
CBA/J MGP_CBAJ_G0009108
 miRNA gene Chr9:117557025-117557109 (+)
DBA/2J MGP_DBA2J_G0009138
 miRNA gene Chr9:105943975-105944059 (+)
FVB/NJ MGP_FVBNJ_G0009156
 miRNA gene Chr9:104705642-104705726 (+)
LP/J MGP_LPJ_G0009235
 miRNA gene Chr9:110730693-110730777 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0009122
 miRNA gene Chr9:119129127-119129211 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0009414
 miRNA gene Chr9:109432899-109432983 (+)
PWK/PhJ MGP_PWKPhJ_G0008898
 miRNA gene Chr9:106269412-106269496 (+)
SPRET/EiJ MGP_SPRETEiJ_G0008737
 miRNA gene Chr9:109495649-109495733 (+)
WSB/EiJ MGP_WSBEiJ_G0009067
 miRNA gene Chr9:109314633-109314717 (+)



Homology
more
  • Human Ortholog
    MIR425, microRNA 425
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR425, microRNA 425
  • Synonyms
    hsa-mir-425, mir-425, MIRN425
  • Links
    NCBI Gene ID: 494337

  • Chr Location
    chr3:49020148-49020234 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a null allele exhibit increased dopaminergic neuron loss and aggravated MPTP-induced motor deficits and dopaminergic neurodegeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      22
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 723864 NCBI Gene Model | MGI Sequence Detail 85 C57BL/6J ±  kb
    transcript NR_029947 RefSeq | MGI Sequence Detail 85 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 2
      Other 2
    Other Database
    Links
    less
    miRBase MI0001447
    References
    more
    • Summaries
      All 14
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 2
    • Earliest
      J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
    • Latest
      J:280159 Hu YB, et al., miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease. Cell Death Dis. 2019 Aug 5;10(8):589
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory