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Mir592 Gene Detail
Summary
  • Symbol
    Mir592
  • Name
    microRNA 592
  • Synonyms
    mir 592, mir-592, Mirn592, mmu-mir-592
  • Feature Type
    miRNA gene
  • IDs
    MGI:3629661
    NCBI Gene: 735266
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:27936654-27936749 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 11.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3629661
 miRNA gene Chr6:27936654-27936749 (-)
129S1/SvImJ MGP_129S1SvImJ_G0008884
 miRNA gene Chr6:25637811-25637906 (-)
A/J MGP_AJ_G0008868
 miRNA gene Chr6:24552937-24553032 (-)
AKR/J MGP_AKRJ_G0008859
 miRNA gene Chr6:25375632-25375727 (-)
BALB/cJ MGP_BALBcJ_G0008856
 miRNA gene Chr6:24716225-24716320 (-)
C3H/HeJ MGP_C3HHeJ_G0008796
 miRNA gene Chr6:25359866-25359961 (-)
C57BL/6NJ MGP_C57BL6NJ_G0009086
 miRNA gene Chr6:26415550-26415645 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0008007
 miRNA gene Chr6:22782257-22782352 (-)
CAST/EiJ MGP_CASTEiJ_G0008639
 miRNA gene Chr6:25153427-25153522 (-)
CBA/J MGP_CBAJ_G0008763
 miRNA gene Chr6:27370382-27370477 (-)
DBA/2J MGP_DBA2J_G0008795
 miRNA gene Chr6:24514624-24514719 (-)
FVB/NJ MGP_FVBNJ_G0008813
 miRNA gene Chr6:24266705-24266800 (-)
LP/J MGP_LPJ_G0008888
 miRNA gene Chr6:25765844-25765939 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0008778
 miRNA gene Chr6:29929642-29929737 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0009062
 miRNA gene Chr6:25250247-25250342 (-)
PWK/PhJ MGP_PWKPhJ_G0008566
 miRNA gene Chr6:24036012-24036107 (-)
SPRET/EiJ MGP_SPRETEiJ_G0008410
 miRNA gene Chr6:24927566-24927661 (-)
WSB/EiJ MGP_WSBEiJ_G0008735
 miRNA gene Chr6:25212334-25212429 (-)



Homology
more
  • Human Ortholog
    MIR592, microRNA 592
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR592, microRNA 592
  • Synonyms
    hsa-mir-592, mir-592, MIRN592
  • Links
    NCBI Gene ID: 693177

  • Chr Location
    chr7:127058088-127058184 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show partial perinatal lethality, with more males affected by lethality. Adults show reduced motor coordination, social interaction, and novel object curiosity, and increased grooming. Cortical neurogenesis is affected, with repressed intermediate progenitor cell to mature neuron transition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      23
    • RefSeq
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 735266 NCBI Gene Model | MGI Sequence Detail 96 C57BL/6J ±  kb
    transcript NR_030420 RefSeq | MGI Sequence Detail 96 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 2
      Primer pair 1
      Other 1
    Other Database
    Links
    less
    miRBase MI0004127
    References
    more
    • Summaries
      All 12
      Developmental Gene Expression 3
      Gene Ontology 1
      Phenotypes 2
    • Earliest
      J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
    • Latest
      J:323615 Fu Y, et al., Loss of neurodevelopmental-associated miR-592 impairs neurogenesis and causes social interaction deficits. Cell Death Dis. 2022 Apr 1;13(4):292
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory