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AY761185 Gene Detail
Summary
  • Symbol
    AY761185
  • Name
    cDNA sequence AY761185
  • Synonyms
    CRS4C-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:3630303
    NCBI Gene: 100503970
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:21433710-21434726 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3630303
 protein coding gene Chr8:21433710-21434764 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033425
 protein coding gene Chr8:18705219-18706262 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0033920
 protein coding gene Chr8:19330656-19331711 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030880
 protein coding gene Chr8:15485946-15486990 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0033339
 protein coding gene Chr8:19185496-19186550 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0033938
 protein coding gene Chr8:18624555-18625610 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0031993
 protein coding gene Chr8:18134732-18135786 (-)
WSB/EiJ MGP_WSBEiJ_G0032558
 protein coding gene Chr8:18785838-18786892 (-)



Homology
more
  • Human Ortholog
    DEFA1, defensin alpha 1
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFA1, defensin alpha 1
  • Synonyms
    DEF1, DEFA2, HNP-1, HP-1, HP1, MRS
  • Links
    NCBI Gene ID: 1667
    neXtProt AC: NX_P59665
    UniProt: P59665

  • Chr Location
    8p23.1; chr8:6977649-6980092 (-)  GRCh38
  • Human Ortholog
    DEFA1B, defensin alpha 1B
  • Synonyms
    HNP-1, HP-1, HP1
  • Links
    NCBI Gene ID: 728358
    neXtProt AC: NX_P59665
    UniProt: P59665

  • Chr Location
    8p23.1; chr8:6996766-6999198 (-)  GRCh38
  • Human Ortholog
    DEFA3, defensin alpha 3
  • Synonyms
    DEF3, HNP-3, HNP3, HP-3, HP3
  • Links
    NCBI Gene ID: 1668
    neXtProt AC: NX_P59666
    UniProt: P59666

  • Chr Location
    8p23.1; chr8:7015869-7018297 (-)  GRCh38
  • Human Ortholog
    DEFA4, defensin alpha 4
  • Synonyms
    DEF4, HNP-4, HP-4, HP4
  • Links
    NCBI Gene ID: 1669
    neXtProt AC: NX_P12838
    UniProt: P12838

  • Chr Location
    8p23.1; chr8:6935820-6938306 (-)  GRCh38
  • Human Ortholog
    DEFA5, defensin alpha 5
  • Synonyms
    DEF5, HD-5
  • Links
    NCBI Gene ID: 1670
    neXtProt AC: NX_Q01523
    UniProt: Q01523

  • Chr Location
    8p23.1; chr8:7055304-7056739 (-)  GRCh38
  • Human Ortholog
    DEFA6, defensin alpha 6
  • Synonyms
    DEF6, HD-6
  • Links
    NCBI Gene ID: 1671
    neXtProt AC: NX_Q01524
    UniProt: Q01524

  • Chr Location
    8p23.1; chr8:6924697-6926076 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079120 Ensembl Gene Model | MGI Sequence Detail 1017 C57BL/6J ±  kb
transcript ENSMUST00000110758 Ensembl | MGI Sequence Detail 448 Not Applicable  
polypeptide ENSMUSP00000106386 Ensembl | MGI Sequence Detail 94 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR016327 Alpha-defensin
    IPR002366 Alpha-defensin, N-terminal
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 11
    Gene Ontology 2
    Phenotypes 1
  • Earliest
    J:95505 Patil A, et al., Rapid evolution and diversification of mammalian alpha-defensins as revealed by comparative analysis of rodent and primate genes. Physiol Genomics. 2004 Dec 15;20(1):1-11
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory