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Dok6 Gene Detail
Summary
  • Symbol
    Dok6
  • Name
    docking protein 6
  • Synonyms
    Dok-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:3639495
    NCBI Gene: 623279
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:89310548-89787652 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 59.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    11154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3639495
 protein coding gene Chr18:89310547-89787664 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024618
 protein coding gene Chr18:90655074-91149405 (-)
A/J MGP_AJ_G0024585
 protein coding gene Chr18:86613126-87075558 (-)
AKR/J MGP_AKRJ_G0024556
 protein coding gene Chr18:89219090-89673367 (-)
BALB/cJ MGP_BALBcJ_G0024583
 protein coding gene Chr18:86895497-87372072 (-)
C3H/HeJ MGP_C3HHeJ_G0024352
 protein coding gene Chr18:89374767-89872877 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025031
 protein coding gene Chr18:92970567-93483057 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022461
 protein coding gene Chr18:85339842-85761072 (-)
CAST/EiJ MGP_CASTEiJ_G0023824
 protein coding gene Chr18:89853260-90348152 (-)
CBA/J MGP_CBAJ_G0024322
 protein coding gene Chr18:96286000-96820499 (-)
DBA/2J MGP_DBA2J_G0024451
 protein coding gene Chr18:86175742-86656995 (-)
FVB/NJ MGP_FVBNJ_G0024418
 protein coding gene Chr18:85496137-85941360 (-)
LP/J MGP_LPJ_G0024536
 protein coding gene Chr18:90518544-91021132 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024448
 protein coding gene Chr18:98164396-98776458 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025079
 protein coding gene Chr18:89521156-90005571 (-)
PWK/PhJ MGP_PWKPhJ_G0023570
 protein coding gene Chr18:86531547-87003087 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023377
 protein coding gene Chr18:89501506-89957355 (-)
WSB/EiJ MGP_WSBEiJ_G0023887
 protein coding gene Chr18:89425722-89914424 (-)



Homology
more
  • Human Ortholog
    DOK6, docking protein 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOK6, docking protein 6
  • Synonyms
    DOK5L, HsT3226
  • Links
    NCBI Gene ID: 220164
    neXtProt AC: NX_Q6PKX4
    UniProt: Q6PKX4

  • Chr Location
    18q22.2; chr18:69400888-69849087 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    14
  • cDNA Data
    6
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073514 Ensembl Gene Model | MGI Sequence Detail 477105 C57BL/6J ±  kb
    transcript ENSMUST00000097495 Ensembl | MGI Sequence Detail 10099 Not Applicable  
    polypeptide ENSMUSP00000095103 Ensembl | MGI Sequence Detail 331 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 22
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 7
    • Earliest
      J:45709 Melloy PG, et al., No turning, a mouse mutation causing left-right and axial patterning defects. Dev Biol. 1998 Jan 1;193(1):77-89
    • Latest
      J:345844 Guo Y, et al., Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory