Krtap12-21 Gene Detail

Summary

• Symbol
  Krtap12-21
• Name
  keratin associated protein 12-21
• Synonyms
  Gm10142

• Feature Type
  protein coding gene
• IDs
  MGI:3641725
  NCBI Gene: 100502921
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr10:77551641-77552003 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 39.72 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  121 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3641725	protein coding gene	Chr10:77551605-77552003 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017405	protein coding gene	Chr10:78060929-78061291 (+)
A/J	MGP_AJ_G0017381	protein coding gene	Chr10:75340322-75340684 (+)
AKR/J	MGP_AKRJ_G0017343	protein coding gene	Chr10:77350378-77350740 (+)
BALB/cJ	MGP_BALBcJ_G0017342	protein coding gene	Chr10:75534433-75534795 (+)
C3H/HeJ	MGP_C3HHeJ_G0017166	protein coding gene	Chr10:77434036-77434398 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017800	protein coding gene	Chr10:80810104-80810466 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015489	protein coding gene	Chr10:71772085-71772447 (+)
CAST/EiJ	MGP_CASTEiJ_G0016736	protein coding gene	Chr10:77798990-77799352 (+)
CBA/J	MGP_CBAJ_G0017138	protein coding gene	Chr10:83909053-83909415 (+)
DBA/2J	MGP_DBA2J_G0017243	protein coding gene	Chr10:74616070-74616432 (+)
FVB/NJ	MGP_FVBNJ_G0017235	protein coding gene	Chr10:73793966-73794328 (+)
LP/J	MGP_LPJ_G0017316	protein coding gene	Chr10:78521863-78522225 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017264	protein coding gene	Chr10:85945166-85945528 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017839	protein coding gene	Chr10:77441351-77441713 (+)
PWK/PhJ	MGP_PWKPhJ_G0016519	protein coding gene	Chr10:74499832-74500194 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016303	protein coding gene	Chr10:76692815-76693237 (+)
WSB/EiJ	MGP_WSBEiJ_G0016798	protein coding gene	Chr10:77413128-77413490 (+)

Homology

• Human Ortholog
  KRTAP12-1, keratin associated protein 12-1

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  KRTAP12-1, keratin associated protein 12-1
  
• Synonyms
  KAP12.1, KRTAP12.1
• Links
  HGNC:20529

  NCBI Gene ID: 353332

  neXtProt AC: NX_P59990

  UniProt: P59990

  
  
• Chr Location
  21q22.3; chr21:44681576-44682163 (-)  GRCh38

---

• Human Ortholog
  KRTAP12-2, keratin associated protein 12-2
  
• Synonyms
  KAP12.2, KRTAP12.2
• Links
  HGNC:20530

  NCBI Gene ID: 353323

  neXtProt AC: NX_P59991

  UniProt: P59991

  
  
• Chr Location
  21q22.3; chr21:44666189-44666927 (-)  GRCh38

---

• Human Ortholog
  KRTAP12-3, keratin associated protein 12-3
  
• Synonyms
  KRTAP12.3
• Links
  HGNC:20531

  NCBI Gene ID: 386683

  neXtProt AC: NX_P60328

  UniProt: P60328

  
  
• Chr Location
  21q22.3; chr21:44657932-44658341 (+)  GRCh38

---

• MGI Vertebrate Homology
  Krtap12-21 stringent orthology
  3 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: KRTAP12-1, KRTAP12-2, KRTAP12-3
• Gene Tree
  Krtap12-21
  

Human Diseases

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  30 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Targeted
  3
• Genomic Mutations
  4 involving Krtap12-21
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  10 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  25
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS56724.1

• Ensembl
  ENSMUSG00000094146 (Evidence)
• NCBI Gene
  100502921

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000094146	Ensembl Gene Model | MGI Sequence Detail	363	C57BL/6J
transcript	ENSMUST00000179767	Ensembl | MGI Sequence Detail	363	Not Applicable
polypeptide	ENSMUSP00000135962	Ensembl | MGI Sequence Detail	120	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR002494 Keratin-associated protein

Other
Accession IDs

MGI:7580933

References

• Summaries
  All 38

  Diseases 2

  Gene Ontology 1

  Phenotypes 30
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599

TSS for Krtap12-21:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94283	Chr10:77551602-77551607 (+)	-36 bp