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Tigit Gene Detail
Summary
  • Symbol
    Tigit
  • Name
    T cell immunoreceptor with Ig and ITIM domains
  • Synonyms
    ENSMUSG00000071552, Vstm3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3642260
    NCBI Gene: 100043314
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:43469230-43484509 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 28.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    424 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3642260
 protein coding gene Chr16:43469224-43485494 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022828
 protein coding gene Chr16:42354012-42371251 (-)
A/J MGP_AJ_G0022793
 protein coding gene Chr16:40440678-40456941 (-)
AKR/J MGP_AKRJ_G0022765
 protein coding gene Chr16:41757139-41773178 (-)
BALB/cJ MGP_BALBcJ_G0022794
 protein coding gene Chr16:40438601-40454352 (-)
C3H/HeJ MGP_C3HHeJ_G0022558
 protein coding gene Chr16:41941851-41957636 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023241
 protein coding gene Chr16:43333912-43350813 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020756
 protein coding gene Chr16:40519537-40533924 (-)
CAST/EiJ MGP_CASTEiJ_G0022084
 protein coding gene Chr16:42146365-42161937 (-)
CBA/J MGP_CBAJ_G0022529
 protein coding gene Chr16:45175684-45195421 (-)
DBA/2J MGP_DBA2J_G0022661
 protein coding gene Chr16:40171989-40190932 (-)
FVB/NJ MGP_FVBNJ_G0022636
 protein coding gene Chr16:40160963-40175278 (-)
LP/J MGP_LPJ_G0022729
 protein coding gene Chr16:42065527-42082595 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022655
 protein coding gene Chr16:44572686-44589638 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023256
 protein coding gene Chr16:41768308-41784591 (-)
PWK/PhJ MGP_PWKPhJ_G0021824
 protein coding gene Chr16:40579346-40594683 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021655
 protein coding gene Chr16:41672305-41691652 (-)
WSB/EiJ MGP_WSBEiJ_G0022128
 protein coding gene Chr16:41871575-41888123 (-)



Homology
more
  • Human Ortholog
    TIGIT, T cell immunoreceptor with Ig and ITIM domains
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIGIT, T cell immunoreceptor with Ig and ITIM domains
  • Synonyms
    VSIG9, VSTM3, WUCAM
  • Links
    NCBI Gene ID: 201633
    neXtProt AC: NX_Q495A1
    UniProt: Q495A1

  • Chr Location
    3q13.31; chr3:114276913-114310288 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased T cell proliferation, antigen presenting cell stimuation of T cell proliferation, and susceptibility to EAE.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071552 Ensembl Gene Model | MGI Sequence Detail 15280 C57BL/6J ±  kb
    transcript ENSMUST00000096065 Ensembl | MGI Sequence Detail 919 Not Applicable  
    polypeptide ENSMUSP00000093770 Ensembl | MGI Sequence Detail 241 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less

    • Microarray probesets 1
    References
    more
    • Summaries
      All 48
      Gene Ontology 8
      Phenotypes 26
    • Earliest
      J:150317 Yu X, et al., The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol. 2009 Jan;10(1):48-57
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory