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H2ab1 Gene Detail
Summary
  • Symbol
    H2ab1
  • Name
    H2A.B variant histone 1
  • Synonyms
    ENSMUSG00000067441, H2A.Bbd1, H2afb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3642445
    NCBI Gene: 100039319
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:115924454-115924801 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 49.58 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3642445
 protein coding gene ChrX:115924454-115924801 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036046
 protein coding gene ChrX:117191030-117191597 (-)
A/J MGP_AJ_G0036021
 protein coding gene ChrX:112757812-112758158 (+)
AKR/J MGP_AKRJ_G0035945
 protein coding gene ChrX:120615373-120615975 (-)
BALB/cJ MGP_BALBcJ_G0036013
 protein coding gene ChrX:111251938-111252284 (+)
C3H/HeJ MGP_C3HHeJ_G0035719
 protein coding gene ChrX:114186888-114187360 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036537
 protein coding gene ChrX:116314091-116314437 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033369
 protein coding gene ChrX:112963695-112964410 (-)
CAST/EiJ MGP_CASTEiJ_G0035007
 protein coding gene ChrX:97914262-97914819 (-)
CBA/J MGP_CBAJ_G0035696
 protein coding gene ChrX:120875391-120875893 (+)
DBA/2J MGP_DBA2J_G0035851
 protein coding gene ChrX:116147450-116148052 (-)
FVB/NJ MGP_FVBNJ_G0035789
 protein coding gene ChrX:111392581-111392927 (+)
LP/J MGP_LPJ_G0035945
 protein coding gene ChrX:118066365-118066952 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035818
 protein coding gene ChrX:125728816-125729162 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036564
 protein coding gene ChrX:112514911-112515257 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0034530
 protein coding gene ChrX:97935905-97936249 (+)
WSB/EiJ MGP_WSBEiJ_G0035142
 protein coding gene ChrX:111237334-111237680 (+)



Homology
more
  • Human Ortholog
    H2AB1, H2A.B variant histone 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H2AB1, H2A.B variant histone 1
  • Synonyms
    H2A.B, H2A.B.2, H2A.Bbd, H2AFB1
  • Links
    NCBI Gene ID: 474382
    neXtProt AC: NX_P0C5Y9
    UniProt: P0C5Y9

  • Chr Location
    Xq28; chrX:154884972-154885558 (+)  GRCh38
  • Human Ortholog
    H2AB2, H2A.B variant histone 2
  • Synonyms
    H2A.B.1, H2AB3, H2A.Bbd, H2AFB2
  • Links
    NCBI Gene ID: 474381
    neXtProt AC: NX_P0C5Z0
    UniProt: P0C5Z0

  • Chr Location
    Xq28; chrX:155380709-155381299 (+)  GRCh38
  • Human Ortholog
    H2AB3, H2A.B variant histone 3
  • Synonyms
    H2A.B.1, H2AB2, H2ABBD, H2AFB, H2AFB3
  • Links
    NCBI Gene ID: 83740
    neXtProt AC: NX_P0C5Z0
    UniProt: P0C5Z0

  • Chr Location
    Xq28; chrX:155459415-155460005 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from multigenic genotypes
    2 phenotype references
Male mice hemizygous for knock-out alleles of H2afb1, H2afb2 and H2afb3 exhibit reduced fertility, teratozoospermia, oligozoospermia and clogged seminiferous tubules.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100039319 NCBI Gene Model | MGI Sequence Detail 348 C57BL/6J ±  kb
transcript NM_001102665 RefSeq | MGI Sequence Detail 348 Not Specified  
polypeptide NP_001096135 RefSeq | MGI Sequence Detail 115 Not Specified  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:6358824
References
more
  • Summaries
    All 16
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:173007 Ishibashi T, et al., H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis. Nucleic Acids Res. 2010 Apr;38(6):1780-9
  • Latest
    J:300161 Molaro A, et al., Biparental contributions of the H2A.B histone variant control embryonic development in mice. PLoS Biol. 2020 Dec;18(12):e3001001
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory