Cep85l MGI Mouse Gene Detail - MGI:3642684 - centrosomal protein 85-like

Symbol

Cep85l
Name

centrosomal protein 85-like
Synonyms

Gm9766

Feature Type

protein coding gene
IDs

MGI:3642684
NCBI Gene: 100038725
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr10:53149539-53256043 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 27.09 cM
Mapping Data

1 experiment

SNPs within 2kb

2625 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3642684	protein coding gene	Chr10:53149537-53256765 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017228	protein coding gene	Chr10:52455494-52560563 (-)
A/J	MGP_AJ_G0017204	protein coding gene	Chr10:50906223-51008263 (-)
AKR/J	MGP_AKRJ_G0017163	protein coding gene	Chr10:51911105-52014198 (-)
BALB/cJ	MGP_BALBcJ_G0017165	protein coding gene	Chr10:51051568-51152460 (-)
C3H/HeJ	MGP_C3HHeJ_G0016987	protein coding gene	Chr10:52162140-52271565 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017624	protein coding gene	Chr10:54101294-54208785 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015318	protein coding gene	Chr10:48081680-48189159 (-)
CAST/EiJ	MGP_CASTEiJ_G0016561	protein coding gene	Chr10:52250433-52365418 (-)
CBA/J	MGP_CBAJ_G0016960	protein coding gene	Chr10:56405641-56520417 (-)
DBA/2J	MGP_DBA2J_G0017065	protein coding gene	Chr10:50348513-50449121 (-)
FVB/NJ	MGP_FVBNJ_G0017059	protein coding gene	Chr10:49643676-49743471 (-)
LP/J	MGP_LPJ_G0017140	protein coding gene	Chr10:52521477-52632986 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017088	protein coding gene	Chr10:58355247-58470206 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017659	protein coding gene	Chr10:51816699-51921137 (-)
PWK/PhJ	MGP_PWKPhJ_G0016342	protein coding gene	Chr10:50184201-50291169 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016127	protein coding gene	Chr10:51423326-51543613 (-)
WSB/EiJ	MGP_WSBEiJ_G0016626	protein coding gene	Chr10:52062863-52167167 (-)

Human Ortholog

CEP85L, centrosomal protein 85 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEP85L, centrosomal protein 85 like
Synonyms

bA57K17.2, C6orf204, LIS10, NY-BR-15
Links

HGNC:21638

NCBI Gene ID: 387119

neXtProt AC: NX_Q5SZL2

UniProt: Q5SZL2
Chr Location

6q22.31; chr6:118460772-118710089 (-) GRCh38

MGI Vertebrate Homology

Cep85l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CEP85L
Gene Tree

Cep85l

Diseases

1 with human CEP85L associations

				Human Disease	Mouse Models
				lissencephaly 10 IDs lissencephaly 10 DOID:0112229 OMIM:618873

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Cep85l
Incidental Mutations

APF
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

6
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cep85l

less

All Sequences

43
RefSeq

10
UniProt

3
CCDS

CCDS56701.1

Ensembl

ENSMUSG00000038594 (Evidence)
NCBI Gene

100038725

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038594	Ensembl Gene Model \| MGI Sequence Detail	106505	C57BL/6J	± kb
transcript	ENSMUST00000220443	Ensembl \| MGI Sequence Detail	7425	Not Applicable
polypeptide	ENSMUSP00000151909	Ensembl \| MGI Sequence Detail	806	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000030310 centrosomal protein of 85 kDa-like

(term hierarchy)
InterPro Domains

IPR040210 Cep85/Cep85L

less

All nucleic 2

cDNA 2

Microarray probesets 1

Summaries

All 28

Gene Ontology 4

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cep85l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97589	Chr10:53255960-53255995 (-)	65 bp
Tssr97588	Chr10:53255912-53255954 (-)	110 bp
Tssr97587	Chr10:53252226-53252260 (-)	3,800 bp
Tssr97586	Chr10:53247917-53247919 (-)	8,125 bp
Tssr97585	Chr10:53237099-53237102 (-)	18,942 bp
Tssr97584	Chr10:53225911-53225923 (-)	30,126 bp
Tssr97583	Chr10:53225877-53225906 (-)	30,151 bp
Tssr97582	Chr10:53224725-53224734 (-)	31,313 bp
Tssr97581	Chr10:53224605-53224613 (-)	31,434 bp
Tssr97580	Chr10:53213413-53213426 (-)	42,623 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24