Angptl8 MGI Mouse Gene Detail - MGI:3643534

Symbol

Angptl8
Name

angiopoietin-like 8
Synonyms

Gm6484, Lipasin, Rifl

Feature Type

protein coding gene
IDs

MGI:3643534
NCBI Gene: 624219
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr9:21746806-21748643 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 7.90 cM
Mapping Data

1 experiment

SNPs within 2kb

114 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3643534	protein coding gene	Chr9:21746806-21748643 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034464	protein coding gene	Chr9:19100463-19102299 (+)
A/J	MGP_AJ_G0034442	protein coding gene	Chr9:18738125-18739961 (+)
AKR/J	MGP_AKRJ_G0034369	protein coding gene	Chr9:19103657-19105493 (+)
BALB/cJ	MGP_BALBcJ_G0034433	protein coding gene	Chr9:18620892-18622728 (+)
C3H/HeJ	MGP_C3HHeJ_G0034145	protein coding gene	Chr9:19400712-19402548 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034954	protein coding gene	Chr9:19851910-19853746 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031884	protein coding gene	Chr9:17842391-17844202 (+)
CAST/EiJ	MGP_CASTEiJ_G0033468	protein coding gene	Chr9:19234968-19236795 (+)
CBA/J	MGP_CBAJ_G0034118	protein coding gene	Chr9:20628642-20630478 (+)
DBA/2J	MGP_DBA2J_G0034277	protein coding gene	Chr9:18705783-18707619 (+)
FVB/NJ	MGP_FVBNJ_G0034220	protein coding gene	Chr9:18245668-18247508 (+)
LP/J	MGP_LPJ_G0034362	protein coding gene	Chr9:19235658-19237498 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034263	protein coding gene	Chr9:22203229-22205069 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034974	protein coding gene	Chr9:19056370-19058206 (+)
PWK/PhJ	MGP_PWKPhJ_G0033173	protein coding gene	Chr9:18707144-18709053 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033008	protein coding gene	Chr9:19103230-19105058 (+)
WSB/EiJ	MGP_WSBEiJ_G0033583	protein coding gene	Chr9:18791231-18793071 (+)

Human Ortholog

ANGPTL8, angiopoietin like 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANGPTL8, angiopoietin like 8
Synonyms

C19orf80, PRO1185, PVPA599, RIFL, TD26
Links

HGNC:24933

NCBI Gene ID: 55908

neXtProt AC: NX_Q6UXH0

UniProt: Q6UXH0
Chr Location

19p13.2; chr19:11237502-11241943 (+) GRCh38

MGI Vertebrate Homology

Angptl8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANGPTL8
Gene Tree

Angptl8

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

5
Spontaneous

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted mutation exhibit markedly reduced serum triglyceride levels.

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All GO Annotations

23
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

4
CCDS

CCDS40556.1

Ensembl

ENSMUSG00000047822 (Evidence)
NCBI Gene

624219

			Length	Strain/Species	Flank
genomic	624219	NCBI Gene Model \| MGI Sequence Detail	1838	C57BL/6J	± kb
transcript	NM_001080940	RefSeq \| MGI Sequence Detail	887	C57BL/6
polypeptide	Q8R1L8	UniProt \| EBI \| MGI Sequence Detail	198	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000059878 angiopoietin-like protein 8

(term hierarchy)
InterPro Domains

IPR026614 Angiopoietin-like protein 8

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All nucleic 10

cDNA 10

Microarray probesets 1

Summaries

All 47

Gene Ontology 12

Phenotypes 21
Earliest

J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
Latest

J:346397 Meng M, et al., Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner. Metabolism. 2024 Jan 9;152:155784

TSS for Angptl8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84050	Chr9:21746785-21746800 (+)	-13 bp
Tssr84051	Chr9:21746802-21746812 (+)	1 bp
Tssr84052	Chr9:21746931-21746942 (+)	131 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24