Ighv3-4 MGI Mouse Gene Detail - MGI:3644034 - immunoglobulin heavy variable V3-4

Symbol

Ighv3-4
Name

immunoglobulin heavy variable V3-4

Feature Type

gene segment
IDs

MGI:3644034
NCBI Gene: 629833
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr12:114217237-114217535 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 62.33 cM
Mapping Data

1 experiment

SNPs within 2kb

147 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3644034	gene segment	Chr12:114217237-114217671 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0000062	gene segment	Chr12:116873236-116873670 (-)
A/J	MGP_AJ_G0000066	gene segment	Chr12:112452513-112452947 (-)
AKR/J	MGP_AKRJ_G0000066	gene segment	Chr12:115720000-115720434 (-)
BALB/cJ	MGP_BALBcJ_G0000063	gene segment	Chr12:112951674-112952108 (-)
C3H/HeJ	MGP_C3HHeJ_G0000063	gene segment	Chr12:116073204-116073638 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0000086	gene segment	Chr12:120514939-120515373 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0000041	gene segment	Chr12:108817444-108817878 (-)
CAST/EiJ	MGP_CASTEiJ_G0000063	gene segment	Chr12:110863845-110864279 (-)
CBA/J	MGP_CBAJ_G0000061	gene segment	Chr12:125078411-125078845 (-)
DBA/2J	MGP_DBA2J_G0000065	gene segment	Chr12:111998646-111999080 (-)
FVB/NJ	MGP_FVBNJ_G0000059	gene segment	Chr12:110694257-110694691 (-)
LP/J	MGP_LPJ_G0000069	gene segment	Chr12:116860193-116860627 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0000067	gene segment	Chr12:128344578-128345012 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0000079	gene segment	Chr12:115123173-115123607 (-)
PWK/PhJ	MGP_PWKPhJ_G0000053	gene segment	Chr12:106635261-106635695 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0000047	gene segment	Chr12:109403798-109404232 (-)
WSB/EiJ	MGP_WSBEiJ_G0000063	gene segment	Chr12:116168396-116168830 (-)

Human Ortholog

IGHV4-28, immunoglobulin heavy variable 4-28

Vertebrate Orthologs

16

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IGHV4-28, immunoglobulin heavy variable 4-28
Synonyms

IGHV428, VH
Links

HGNC:5645

NCBI Gene ID: 28400

UniProt: A0A0C4DH34
Chr Location

14q32.33; chr14:106324254-106324760 (-) GRCh38

Human Ortholog

IGHV4-30-2, immunoglobulin heavy variable 4-30-2
Synonyms

IGHV4-3, IGHV4302
Links

HGNC:5647

NCBI Gene ID: 28398
Chr Location

14q32.33; chr14:106349283-106349720 (-) GRCh38

Human Ortholog

IGHV4-31, immunoglobulin heavy variable 4-31
Synonyms

IGHV431
Links

HGNC:5649

NCBI Gene ID: 28396

UniProt: P0DP07
Chr Location

14q32.33; chr14:106349283-106349792 (-) GRCh38

Human Ortholog

IGHV4-34, immunoglobulin heavy variable 4-34
Synonyms

IGHV434, VH
Links

HGNC:5650

NCBI Gene ID: 28395

UniProt: P06331
Chr Location

14q32.33; chr14:106373661-106374145 (-) GRCh38

Human Ortholog

IGHV4-38-2, immunoglobulin heavy variable 4-38-2
Synonyms

IGHV4-B, IGHV4B
Links

HGNC:5657

NCBI Gene ID: 28389

UniProt: P0DP08
Chr Location

14q32.33

Human Ortholog

IGHV4-39, immunoglobulin heavy variable 4-39
Synonyms

IGHV439, VH
Links

HGNC:5651

NCBI Gene ID: 28394

UniProt: P01824
Chr Location

14q32.33; chr14:106421709-106422218 (-) GRCh38

Human Ortholog

IGHV4-4, immunoglobulin heavy variable 4-4
Synonyms

IGHV44, VH
Links

HGNC:5652

NCBI Gene ID: 28401

UniProt: A0A075B6R2
Chr Location

14q32.33; chr14:106011922-106012420 (-) GRCh38

Human Ortholog

IGHV4-59, immunoglobulin heavy variable 4-59
Synonyms

IGHV459, VH
Links

HGNC:5654

NCBI Gene ID: 28392

UniProt: P01825
Chr Location

14q32.33; chr14:106627249-106627825 (-) GRCh38

Human Ortholog

IGHV4-61, immunoglobulin heavy variable 4-61
Synonyms

IGHV461, VH
Links

HGNC:5655

NCBI Gene ID: 28391

UniProt: A0A0C4DH41
Chr Location

14q32.33; chr14:106639119-106639657 (-) GRCh38

Human Ortholog

IGHV4OR15-8, immunoglobulin heavy variable 4/OR15-8 (non-functional)
Synonyms

IGHV4OR158, VSIG6
Links

HGNC:5658

NCBI Gene ID: 28317
Chr Location

15q11.2; chr15:22184967-22185402 (-) GRCh38

Human Ortholog

IGHV6-1, immunoglobulin heavy variable 6-1
Synonyms

IGHV61, VH
Links

HGNC:5662

NCBI Gene ID: 28385

UniProt: A0A0B4J1U7
Chr Location

14q32.33; chr14:105939754-105940253 (-) GRCh38

MGI Vertebrate Homology

Ighv3-4 stringent orthology
11 human;1 mouse;5 zebrafish
HCOP

vertebrate homology predictions: IGHV4-28, IGHV4-30-2, IGHV4-31, IGHV4-34, IGHV4-38-2, IGHV4-39, IGHV4-4, IGHV4-59, IGHV4-61, IGHV4OR15-8, IGHV6-1
Gene Tree

Ighv3-4

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All GO Annotations

2
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706

Tissue x Stage Matrix

Other Mouse Links

Expression Atlas

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All Sequences

24
RefSeq

1
UniProt

1

Ensembl

ENSMUSG00000103939 (Evidence)
NCBI Gene

629833

Representative Sequences				Length	Strain/Species	Flank
	genomic	629833	NCBI Gene Model \| MGI Sequence Detail	299	C57BL/6J	± kb
	polypeptide	A0A0A6YXF1	UniProt \| EBI \| MGI Sequence Detail	117	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR050199 Immunoglobulin Heavy Variable

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR013106 Immunoglobulin V-set domain

Summaries

All 7

Gene Ontology 1
Earliest

J:164272 Giudicelli V, et al., IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D256-61

TSS for Ighv3-4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118067	Chr12:114217717-114217724 (-)	-186 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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