About   Help   FAQ
C1s2 Gene Detail
Summary
  • Symbol
    C1s2
  • Name
    complement component 1, s subcomponent 2
  • Synonyms
    Gm5077
  • Feature Type
    protein coding gene
  • IDs
    MGI:3644269
    NCBI Gene: 317677
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124601584-124613044 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    445 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3644269
 protein coding gene Chr6:124601584-124613044 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0031227
 protein coding gene Chr6:123099758-123127152 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0031235
 protein coding gene Chr6:122669935-122702748 (-)
C3H/HeJ MGP_C3HHeJ_G0030958
 protein coding gene Chr6:126378598-126400031 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0030919
 protein coding gene Chr6:136322005-136336117 (-)
DBA/2J MGP_DBA2J_G0031075
 protein coding gene Chr6:122028218-122043654 (-)
FVB/NJ MGP_FVBNJ_G0031025
 protein coding gene Chr6:120942484-120954201 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0031063
 protein coding gene Chr6:140255342-140278302 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031726
 protein coding gene Chr6:126355786-126369297 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0030424
 protein coding gene Chr6:126694537-126728857 (-)



Homology
more
  • Human Ortholog
    C1S, complement C1s
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C1S, complement C1s
  • Synonyms
    EDSPD2
  • Links
    NCBI Gene ID: 716
    neXtProt AC: NX_P09871
    UniProt: P09871

  • Chr Location
    12p13.31; chr12:6988259-7071032 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human C1S associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 317677 NCBI Gene Model | MGI Sequence Detail 11461 C57BL/6J ±  kb
transcript NM_173864 RefSeq | MGI Sequence Detail 2662 C57BL/6  
polypeptide Q8CFG8 UniProt | EBI | MGI Sequence Detail 688 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 22
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:320127 Rossi V, et al., Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2. J Biol Chem. 2001 Nov 2;276(44):40880-7
  • Latest
    J:319954 Mortensen SA, et al., Structure and activation of C1, the complex initiating the classical pathway of the complement cascade. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):986-991
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory