Cdc20b MGI Mouse Gene Detail - MGI:3644472

Symbol

Cdc20b
Name

cell division cycle 20B
Synonyms

EG238896, EG622422

Feature Type

protein coding gene
IDs

MGI:3644472
NCBI Gene: 238896
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr13:113171645-113227729 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 63.93 cM
Mapping Data

1 experiment

SNPs within 2kb

1756 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3644472	protein coding gene	Chr13:113171514-113257553 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020945	protein coding gene	Chr13:115642237-115706108 (+)
A/J	MGP_AJ_G0020895	protein coding gene	Chr13:111015752-111074731 (+)
AKR/J	MGP_AKRJ_G0020870	protein coding gene	Chr13:114365829-114423092 (+)
BALB/cJ	MGP_BALBcJ_G0020895	protein coding gene	Chr13:111711330-111771827 (+)
C3H/HeJ	MGP_C3HHeJ_G0020684	protein coding gene	Chr13:114156192-114219013 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021331	protein coding gene	Chr13:119063584-119137130 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018900	protein coding gene	Chr13:106306026-106364406 (+)
CAST/EiJ	MGP_CASTEiJ_G0020204	protein coding gene	Chr13:113797741-113859482 (+)
CBA/J	MGP_CBAJ_G0020646	protein coding gene	Chr13:123670068-123725507 (+)
DBA/2J	MGP_DBA2J_G0020769	protein coding gene	Chr13:110727193-110789244 (+)
FVB/NJ	MGP_FVBNJ_G0020753	protein coding gene	Chr13:109427806-109485635 (+)
LP/J	MGP_LPJ_G0020845	protein coding gene	Chr13:115675883-115746883 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020781	protein coding gene	Chr13:123924294-124001192 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021367	protein coding gene	Chr13:113831387-113896757 (+)
PWK/PhJ	MGP_PWKPhJ_G0019957	protein coding gene	Chr13:109477393-109541403 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019779	protein coding gene	Chr13:110145461-110201621 (+)
WSB/EiJ	MGP_WSBEiJ_G0020261	protein coding gene	Chr13:114428008-114488982 (+)

Human Ortholog

CDC20B, cell division cycle 20B

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDC20B, cell division cycle 20B
Synonyms

G6VTS76519
Links

HGNC:24222

NCBI Gene ID: 166979

neXtProt AC: NX_Q86Y33

UniProt: Q86Y33
Chr Location

5q11.2; chr5:55112971-55173177 (-) GRCh38

MGI Vertebrate Homology

Cdc20b stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: CDC20B
Gene Tree

Cdc20b

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

2 involving Cdc20b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdc20b

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All Sequences

54
RefSeq

19
UniProt

5
CCDS

CCDS59591.1

Ensembl

ENSMUSG00000078926 (Evidence)
NCBI Gene

238896

			Length	Strain/Species	Flank
genomic	ENSMUSG00000078926	Ensembl Gene Model \| MGI Sequence Detail	56085	C57BL/6J	± kb
transcript	ENSMUST00000109244	Ensembl \| MGI Sequence Detail	1620	Not Applicable
polypeptide	ENSMUSP00000104867	Ensembl \| MGI Sequence Detail	519	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005189 cell division cycle protein 20 homolog B

(term hierarchy)
InterPro Domains

IPR024977 Anaphase-promoting complex subunit 4-like, WD40 domain

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR033010 WD repeat Cdc20/Fizzy

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Microarray probesets 1

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MGI:3648570

Summaries

All 21

Gene Ontology 5

Phenotypes 7
Earliest

J:269158 Revinski DR, et al., CDC20B is required for deuterosome-mediated centriole production in multiciliated cells. Nat Commun. 2018 Nov 7;9(1):4668
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdc20b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121165	Chr13:113171761-113171765 (+)	118 bp
Tssr121167	Chr13:113184924-113184935 (+)	13,285 bp
Tssr4179	Chr13:113207874-113207892 (+)	36,238 bp
Tssr121168	Chr13:113207996-113208011 (+)	36,359 bp
Tssr121169	Chr13:113222766-113222786 (+)	51,131 bp
Tssr121170	Chr13:113224450-113224478 (+)	52,819 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24