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Rbm46 Gene Detail
Summary
  • Symbol
    Rbm46
  • Name
    RNA binding motif protein 46
  • Synonyms
    ENSMUSG00000033882, LOC329687
  • Feature Type
    protein coding gene
  • IDs
    MGI:3645057
    NCBI Gene: 633285
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:82744535-82783790 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 36.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    951 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645057
 protein coding gene Chr3:82743828-82783828 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027329
 protein coding gene Chr3:82654739-82696087 (-)
A/J MGP_AJ_G0027293
 protein coding gene Chr3:79930119-79969310 (-)
AKR/J MGP_AKRJ_G0027259
 protein coding gene Chr3:81837004-81877702 (-)
BALB/cJ MGP_BALBcJ_G0027302
 protein coding gene Chr3:80020690-80061815 (-)
C3H/HeJ MGP_C3HHeJ_G0027046
 protein coding gene Chr3:82110494-82150473 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027748
 protein coding gene Chr3:85772199-85815448 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025101
 protein coding gene Chr3:75665158-75700884 (-)
CAST/EiJ MGP_CASTEiJ_G0026493
 protein coding gene Chr3:82306928-82347894 (-)
CBA/J MGP_CBAJ_G0027021
 protein coding gene Chr3:88679921-88722695 (-)
DBA/2J MGP_DBA2J_G0027157
 protein coding gene Chr3:79476606-79519345 (-)
FVB/NJ MGP_FVBNJ_G0027125
 protein coding gene Chr3:77762339-77801724 (-)
LP/J MGP_LPJ_G0027265
 protein coding gene Chr3:83646059-83686817 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027144
 protein coding gene Chr3:95059384-95105753 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027806
 protein coding gene Chr3:81622950-81664245 (-)
PWK/PhJ MGP_PWKPhJ_G0026227
 protein coding gene Chr3:79231049-79272333 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026043
 protein coding gene Chr3:80820994-80863407 (-)
WSB/EiJ MGP_WSBEiJ_G0026571
 protein coding gene Chr3:81965046-82005581 (-)



Homology
more
  • Human Ortholog
    RBM46, RNA binding motif protein 46
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBM46, RNA binding motif protein 46
  • Synonyms
    CT68
  • Links
    NCBI Gene ID: 166863
    neXtProt AC: NX_Q8TBY0
    UniProt: Q8TBY0

  • Chr Location
    4q32.1; chr4:154781213-154828813 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with a homozygous frameshifting deletion between exons 2-3 exhibit infertility, with absence of oocytes, small testes and seminiferous tubules containing only Sertoli cells and few undifferentiated spermatogonia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    795
  • Tissues
    32
  • cDNA Data
    3
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033882 Ensembl Gene Model | MGI Sequence Detail 39256 C57BL/6J ±  kb
    transcript ENSMUST00000048647 Ensembl | MGI Sequence Detail 1794 Not Applicable  
    polypeptide ENSMUSP00000045511 Ensembl | MGI Sequence Detail 533 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000030975 probable RNA-binding protein 46
      (term hierarchy)
    • InterPro Domains
      IPR006535 HnRNP R/Q splicing factor
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR034434 Probable RNA-binding protein 46, RNA recognition motif 1
      IPR034435 Probable RNA-binding protein 46, RNA recognition motif 2
      IPR047837 Probable RNA-binding protein 46, RNA recognition motif 3
      IPR044462 RBM46, double-stranded RNA binding domain
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 3
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685607, MGI:3642723
    References
    more
    • Summaries
      All 23
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:335675 Lv Y, et al., RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits. Protein Cell. 2023 Jan;14(1):51-63
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory