Lce3a MGI Mouse Gene Detail - MGI:3645650 - late cornified envelope 3A

Symbol

Lce3a
Name

late cornified envelope 3A
Synonyms

EG545548

Feature Type

protein coding gene
IDs

MGI:3645650
NCBI Gene: 545548
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr3:92832594-92833537 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.14 cM
Mapping Data

1 experiment

SNPs within 2kb

171 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3645650	protein coding gene	Chr3:92832591-92833553 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027522	protein coding gene	Chr3:93396597-93398456 (-)
A/J	MGP_AJ_G0027489	protein coding gene	Chr3:90452288-90453952 (-)
AKR/J	MGP_AKRJ_G0027454	protein coding gene	Chr3:92574421-92576367 (-)
BALB/cJ	MGP_BALBcJ_G0027497	protein coding gene	Chr3:90263430-90264715 (-)
C3H/HeJ	MGP_C3HHeJ_G0027235	protein coding gene	Chr3:92792280-92794601 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027939	protein coding gene	Chr3:96943346-96944289 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025288	protein coding gene	Chr3:87074406-87075383 (-)
CAST/EiJ	MGP_CASTEiJ_G0026683	protein coding gene	Chr3:92218921-92219869 (-)
CBA/J	MGP_CBAJ_G0027211	protein coding gene	Chr3:100266010-100266953 (-)
DBA/2J	MGP_DBA2J_G0027348	protein coding gene	Chr3:89782068-89783011 (-)
FVB/NJ	MGP_FVBNJ_G0027316	protein coding gene	Chr3:87940228-87941171 (-)
LP/J	MGP_LPJ_G0027456	protein coding gene	Chr3:94609311-94610571 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027342	protein coding gene	Chr3:106563012-106563955 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027999	protein coding gene	Chr3:92315170-92318382 (-)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0026765	protein coding gene	Chr3:92677920-92679355 (-)

Human Ortholog

LCE3B, late cornified envelope 3B

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LCE3B, late cornified envelope 3B
Synonyms

LEP14
Links

HGNC:29462

NCBI Gene ID: 353143

neXtProt AC: NX_Q5TA77

UniProt: Q5TA77
Chr Location

1q21.3; chr1:152613811-152614098 (+) GRCh38

Human Ortholog

LCE3C, late cornified envelope 3C
Synonyms

LEP15, SPRL3A
Links

HGNC:16612

NCBI Gene ID: 353144

neXtProt AC: NX_Q5T5A8

UniProt: Q5T5A8
Chr Location

1q21.3; chr1:152600234-152601086 (+) GRCh38

Human Ortholog

LCE3D, late cornified envelope 3D
Synonyms

LEP16, SPRL6A, SPRL6B
Links

HGNC:16615

NCBI Gene ID: 84648

neXtProt AC: NX_Q9BYE3

UniProt: Q9BYE3
Chr Location

1q21.3; chr1:152579381-152580516 (-) GRCh38

Human Ortholog

LCE3E, late cornified envelope 3E
Synonyms

LEP17
Links

HGNC:29463

NCBI Gene ID: 353145

neXtProt AC: NX_Q5T5B0

UniProt: Q5T5B0
Chr Location

1q21.3; chr1:152565654-152566780 (-) GRCh38

MGI Vertebrate Homology

Lce3a stringent orthology
4 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LCE3B, LCE3C, LCE3D, LCE3E
Gene Tree

Lce3a

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References

1 with disease annotations

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Phenotype Summary

6 phenotype references

All Mutations and Alleles

4
Chemically induced (other)

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Lce3a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

4 strains or lines available

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Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

1
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

26
RefSeq

2
UniProt

1
CCDS

CCDS38519.1

Ensembl

ENSMUSG00000054325 (Evidence)
NCBI Gene

545548

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054325	Ensembl Gene Model \| MGI Sequence Detail	944	C57BL/6J	± kb
transcript	ENSMUST00000067318	Ensembl \| MGI Sequence Detail	549	Not Applicable
polypeptide	ENSMUSP00000066468	Ensembl \| MGI Sequence Detail	98	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR028205 Late cornified envelope protein

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All nucleic 1

cDNA 1

Microarray probesets 3

Summaries

All 20

Developmental Gene Expression 2

Diseases 1

Phenotypes 6
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Lce3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34340	Chr3:92833549-92833554 (-)	-15 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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