Slc22a28 MGI Mouse Gene Detail - MGI:3645714 - solute carrier family 22, member 28

Slc22a28 Gene Detail

Symbol

Slc22a28
Name

solute carrier family 22, member 28
Synonyms

Gm5631

Feature Type

protein coding gene
IDs

MGI:3645714
NCBI Gene: 434674
Alliance

gene page

Sequence Map

Chr19:8039574-8109346 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.39 cM
Mapping Data

1 experiment

SNPs within 2kb

1838 from dbSNP Build 142
Strain Annotations

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3645714	protein coding gene	Chr19:8039323-8109346 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	MGP_AKRJ_G0024741	protein coding gene	Chr19:4780541-5434245 (-)
BALB/cJ	MGP_BALBcJ_G0024767	protein coding gene	Chr19:4998585-5125470 (-)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0025213	protein coding gene	Chr19:5355835-5460899 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0024601	protein coding gene	Chr19:5207549-5274673 (-)
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0025261	protein coding gene	Chr19:4948318-5464708 (-)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

SLC22A10, solute carrier family 22 member 10

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC22A10, solute carrier family 22 member 10
Synonyms

hOAT5, OAT5
Links

HGNC:18057

NCBI Gene ID: 387775

neXtProt AC: NX_Q63ZE4

UniProt: Q63ZE4
Chr Location

11q12.3

Human Ortholog

SLC22A25, solute carrier family 22 member 25
Synonyms

HIMTP, UST6
Links

HGNC:32935

NCBI Gene ID: 387601

neXtProt AC: NX_Q6T423

UniProt: Q6T423
Chr Location

11q12.3; chr11:63158437-63243599 (-) GRCh38

Human Ortholog

SLC22A9, solute carrier family 22 member 9
Synonyms

HOAT4, OAT4, OAT7, ust3, UST3H
Links

HGNC:16261

NCBI Gene ID: 114571

neXtProt AC: NX_Q8IVM8

UniProt: Q8IVM8
Chr Location

11q12.3; chr11:63369785-63410294 (+) GRCh38

MGI Vertebrate Homology

Slc22a28 stringent orthology
3 human;1 mouse;2 rat
HCOP

vertebrate homology predictions: SLC22A10, SLC22A25, SLC22A9
Gene Tree

Slc22a28

Diseases

2 with human SLC22A9 associations

				Human Disease	Mouse Models
				Lynch syndrome IDs Lynch syndrome DOID:3883 DOID:0050586 DOID:3040 MESH:D003123 NCI:C8494 OMIM:PS120435 ORDO:144 UMLS_CUI:C0009405 UMLS_CUI:C4552100
				mismatch repair cancer syndrome IDs mismatch repair cancer syndrome DOID:0112182 OMIM:276300 ORDO:252202

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotype references

All Mutations and Alleles

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

12
cDNA Data

11
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

28
RefSeq

14
UniProt

2
CCDS

CCDS29534.1

Ensembl

ENSMUSG00000063590 (Evidence)
NCBI Gene

434674

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063590	Ensembl Gene Model \| MGI Sequence Detail	69773	C57BL/6J	± kb
transcript	ENSMUST00000065651	Ensembl \| MGI Sequence Detail	2004	Not Applicable
polypeptide	ENSMUSP00000067114	Ensembl \| MGI Sequence Detail	552	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

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All nucleic 12

cDNA 11

Primer pair 1

Summaries

All 14

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 2
Earliest

J:157965 Wu W, et al., Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Physiol Genomics. 2009 Jul 9;38(2):116-24
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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