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Lekr1 Gene Detail
Summary
  • Symbol
    Lekr1
  • Name
    leucine, glutamate and lysine rich 1
  • Synonyms
    EG546798, Gm6534
  • Feature Type
    protein coding gene
  • IDs
    MGI:3645902
    NCBI Gene: 624866
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:65573649-65738776 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 30.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4543 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645902
 protein coding gene Chr3:65566960-65743948 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027273
 protein coding gene Chr3:64788176-64958258 (+)
A/J MGP_AJ_G0027234
 protein coding gene Chr3:62911244-63077396 (+)
AKR/J MGP_AKRJ_G0027203
 protein coding gene Chr3:64195102-64363051 (+)
BALB/cJ MGP_BALBcJ_G0027246
 protein coding gene Chr3:62733149-62895536 (+)
C3H/HeJ MGP_C3HHeJ_G0026990
 protein coding gene Chr3:64484151-64651064 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027692
 protein coding gene Chr3:67227269-67394652 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025045
 protein coding gene Chr3:59300224-59462997 (+)
CAST/EiJ MGP_CASTEiJ_G0026437
 protein coding gene Chr3:64433320-64621962 (+)
CBA/J MGP_CBAJ_G0026965
 protein coding gene Chr3:69310870-69486237 (+)
DBA/2J MGP_DBA2J_G0027101
 protein coding gene Chr3:62408492-62576373 (+)
FVB/NJ MGP_FVBNJ_G0027069
 protein coding gene Chr3:61055191-61221104 (+)
LP/J MGP_LPJ_G0027209
 protein coding gene Chr3:65707342-65877664 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027087
 protein coding gene Chr3:73922125-74096517 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027750
 protein coding gene Chr3:64104788-64272894 (+)
PWK/PhJ MGP_PWKPhJ_G0026171
 protein coding gene Chr3:62160296-62324533 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025987
 protein coding gene Chr3:63303315-63469627 (+)
WSB/EiJ MGP_WSBEiJ_G0026515
 protein coding gene Chr3:64238462-64411546 (+)



Homology
more
  • Human Ortholog
    LEKR1, leucine, glutamate and lysine rich 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LEKR1, leucine, glutamate and lysine rich 1
  • Links
    NCBI Gene ID: 389170
    neXtProt AC: NX_Q6ZMV7
    UniProt: Q6ZMV7

  • Chr Location
    3q25.31; chr3:156825481-157046129 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Lekr1
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    18 strains or lines available
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074579 Ensembl Gene Model | MGI Sequence Detail 165128 C57BL/6J ±  kb
transcript ENSMUST00000177434 Ensembl | MGI Sequence Detail 2354 Not Applicable  
polypeptide ENSMUSP00000158835 Ensembl | MGI Sequence Detail 690 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR038799 Protein LEKR1
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
Other
Accession IDs
less
MGI:3646741
References
more
  • Summaries
    All 18
    Diseases 1
    Phenotypes 8
  • Earliest
    J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory