Cbr1b MGI Mouse Gene Detail - MGI:3646098

Symbol

Cbr1b
Name

carbonyl reductase 1B
Synonyms

Gm5678

Feature Type

protein coding gene

BioType Conflict
IDs

MGI:3646098
NCBI Gene: 435489
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:93424985-93427339 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 54.54 cM
Mapping Data

1 experiment

SNPs within 2kb

419 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3646098	protein coding gene	Chr16:93424872-93427351 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0040112	pseudogene	Chr16:94818998-94821300 (+)
A/J	MGP_AJ_G0040109	pseudogene	Chr16:90343891-90400974 (+)
AKR/J	MGP_AKRJ_G0040035	pseudogene	Chr16:93096408-93098670 (+)
BALB/cJ	MGP_BALBcJ_G0040091	pseudogene	Chr16:90874232-90877025 (+)
C3H/HeJ	MGP_C3HHeJ_G0039743	pseudogene	Chr16:93614292-93616559 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0040686	pseudogene	Chr16:97801340-97808391 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0038833	pseudogene	Chr16:94327992-94330240 (+)
CBA/J	MGP_CBAJ_G0039710	pseudogene	Chr16:102040465-102042731 (+)
DBA/2J	MGP_DBA2J_G0039902	pseudogene	Chr16:90237017-90291413 (+)
FVB/NJ	MGP_FVBNJ_G0039864	pseudogene	Chr16:89374233-89446113 (+)
LP/J	MGP_LPJ_G0039951	pseudogene	Chr16:94489853-94492162 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0039851	pseudogene	Chr16:106441099-106445103 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0040777	pseudogene	Chr16:93605952-93636815 (+)
PWK/PhJ	MGP_PWKPhJ_G0038526	pseudogene	Chr16:90506005-90508495 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0038241	pseudogene	Chr16:93175589-93178832 (+)
WSB/EiJ	MGP_WSBEiJ_G0039060	pseudogene	Chr16:93884473-93886762 (+)

Human Ortholog

CBR1, carbonyl reductase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CBR1, carbonyl reductase 1
Synonyms

CBR, hCBR1, PG-9-KR, SDR21C1
Links

HGNC:1548

NCBI Gene ID: 873

neXtProt AC: NX_P16152

UniProt: P16152
Chr Location

21q22.12; chr21:36069941-36073166 (+) GRCh38

MGI Vertebrate Homology

Cbr1b stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: CBR1
Gene Tree

Cbr1b

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References

4 with disease annotations

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Phenotype Summary

66 phenotype references

All Mutations and Alleles

7
Endonuclease-mediated

2
Spontaneous

1
Targeted

3
Genomic Mutations

5 involving Cbr1b
Find Mice (IMSR)

5 strains or lines available

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All GO Annotations

10
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

23
RefSeq

1
UniProt

1

Ensembl

ENSMUSG00000082815 (Evidence)
NCBI Gene

435489

			Length	Strain/Species	Flank
genomic	ENSMUSG00000082815	Ensembl Gene Model \| MGI Sequence Detail	2355	C57BL/6J	± kb
transcript	ENSMUST00000120115	Ensembl \| MGI Sequence Detail	939	Not Applicable
polypeptide	ENSMUSP00000147517	Ensembl \| MGI Sequence Detail	277	Not Applicable

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UniProt

1 Sequence
EC

1.1.1.184
InterPro Domains

IPR045313 Carbonyl reductase [NADPH] 1-like

IPR036291 NAD(P)-binding domain superfamily

IPR002347 Short-chain dehydrogenase/reductase SDR

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MGI:7484386

Summaries

All 74

Diseases 4

Gene Ontology 3

Phenotypes 66
Earliest

J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
Latest

J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883

TSS for Cbr1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139510	Chr16:93424913-93424931 (+)	-63 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24