Frmpd3 Gene Detail

Summary

• Symbol
  Frmpd3
• Name
  FERM and PDZ domain containing 3
• Synonyms
  EG245643

• Feature Type
  protein coding gene
• IDs
  MGI:3646547
  NCBI Gene: 245643
• Alliance
  gene page

Location &
Maps

• Sequence Map
  ChrX:139243012-139336216 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome X, 61.35 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  1757 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3646547	protein coding gene	ChrX:139177867-139336216 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036133	protein coding gene	ChrX:137879053-137980997 (+)
A/J	MGP_AJ_G0036111	protein coding gene	ChrX:137263152-137359921 (+)
AKR/J	MGP_AKRJ_G0036036	protein coding gene	ChrX:141656905-141763434 (+)
BALB/cJ	MGP_BALBcJ_G0036101	protein coding gene	ChrX:135580467-135676543 (+)
C3H/HeJ	MGP_C3HHeJ_G0035810	protein coding gene	ChrX:137891776-137991543 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036626	protein coding gene	ChrX:141922311-142027003 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033450	protein coding gene	ChrX:128981708-129075688 (+)
CAST/EiJ	MGP_CASTEiJ_G0035101	protein coding gene	ChrX:118712967-118808174 (+)
CBA/J	MGP_CBAJ_G0035787	protein coding gene	ChrX:146279512-146383846 (+)
DBA/2J	MGP_DBA2J_G0035944	protein coding gene	ChrX:136410420-136505635 (+)
FVB/NJ	MGP_FVBNJ_G0035878	protein coding gene	ChrX:135643179-135736179 (+)
LP/J	MGP_LPJ_G0036035	protein coding gene	ChrX:138830746-138930335 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035915	protein coding gene	ChrX:153792504-153900021 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036662	protein coding gene	ChrX:137188218-137283908 (+)
PWK/PhJ	MGP_PWKPhJ_G0034794	protein coding gene	ChrX:115611075-115706228 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034620	protein coding gene	ChrX:119273045-119303213 (+)
WSB/EiJ	MGP_WSBEiJ_G0035236	protein coding gene	ChrX:135542173-135569873 (+)

Homology

• Human Ortholog
  FRMPD3, FERM and PDZ domain containing 3

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FRMPD3, FERM and PDZ domain containing 3
  
• Links
  HGNC:29382

  NCBI Gene ID: 84443

  neXtProt AC: NX_Q5JV73

  UniProt: Q5JV73

  
  
• Chr Location
  Xq22.3; chrX:107449652-107605255 (+)  GRCh38

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• MGI Vertebrate Homology
  Frmpd3 stringent orthology
  1 human;1 mouse;1 zebrafish
  
• HCOP
  vertebrate homology predictions: FRMPD3
• Gene Tree
  Frmpd3
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  6
• Endonuclease-mediated
  4
• Targeted
  2
• Find Mice (IMSR)
  6 strains or lines available

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  706
• cDNA Data
  7

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase frmpd3

Sequences &
Gene Models

• All Sequences
  49
• RefSeq
  15
• UniProt
  3
• CCDS
  CCDS41149.1, CCDS85809.1

• Ensembl
  ENSMUSG00000042425 (Evidence)
• NCBI Gene
  245643

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000042425	Ensembl Gene Model | MGI Sequence Detail	93205	C57BL/6J
transcript	ENSMUST00000208130	Ensembl | MGI Sequence Detail	7314	Not Applicable
polypeptide	ENSMUSP00000146983	Ensembl | MGI Sequence Detail	1774	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• InterPro Domains
  IPR019749 Band 4.1 domain
  IPR049385 FAK1-like, FERM domain C-lobe
  IPR014352 FERM/acyl-CoA-binding protein superfamily
  IPR041779 FERM and PDZ domain-containing protein 1/3/4, FERM domain C-lobe
  IPR019748 FERM central domain
  IPR000299 FERM domain
  IPR035963 FERM superfamily, second domain
  IPR001478 PDZ domain
  IPR036034 PDZ superfamily
  IPR011993 PH-like domain superfamily
  IPR000159 Ras-associating domain
  IPR029071 Ubiquitin-like domain superfamily
• GlyGen
  A0A140LIW3 2 sites, 1 O-linked glycan (2 sites)

Molecular
Reagents

• All nucleic 7

  cDNA 7

  
  

  Microarray probesets 2

References

• Summaries
  All 18

  Phenotypes 5
• Earliest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;