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Siglec15 Gene Detail
Summary
  • Symbol
    Siglec15
  • Name
    sialic acid binding Ig-like lectin 15
  • Synonyms
    Cd33l3, EG620235
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646642
    NCBI Gene: 620235
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:78086829-78100610 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 52.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    506 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646642
 protein coding gene Chr18:78085708-78100656 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024582
 protein coding gene Chr18:78840769-78856082 (-)
A/J MGP_AJ_G0024549
 protein coding gene Chr18:75385687-75399463 (-)
AKR/J MGP_AKRJ_G0024520
 protein coding gene Chr18:77606082-77619853 (-)
BALB/cJ MGP_BALBcJ_G0024548
 protein coding gene Chr18:75576399-75590842 (-)
C3H/HeJ MGP_C3HHeJ_G0024317
 protein coding gene Chr18:77711832-77725599 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024995
 protein coding gene Chr18:80894089-80907842 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022425
 protein coding gene Chr18:74336853-74350639 (-)
CAST/EiJ MGP_CASTEiJ_G0023789
 protein coding gene Chr18:78035999-78053202 (-)
CBA/J MGP_CBAJ_G0024286
 protein coding gene Chr18:83795688-83809446 (-)
DBA/2J MGP_DBA2J_G0024416
 protein coding gene Chr18:74926984-74940739 (-)
FVB/NJ MGP_FVBNJ_G0024382
 protein coding gene Chr18:74284752-74301961 (-)
LP/J MGP_LPJ_G0024500
 protein coding gene Chr18:78730462-78744114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024412
 protein coding gene Chr18:85007035-85021166 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025043
 protein coding gene Chr18:77786362-77800154 (-)
PWK/PhJ MGP_PWKPhJ_G0023534
 protein coding gene Chr18:75360412-75374610 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023338
 protein coding gene Chr18:77964826-77978625 (-)
WSB/EiJ MGP_WSBEiJ_G0023853
 protein coding gene Chr18:77735316-77749039 (-)



Homology
more
  • Human Ortholog
    SIGLEC15, sialic acid binding Ig like lectin 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIGLEC15, sialic acid binding Ig like lectin 15
  • Synonyms
    CD33L3, HsT1361, SIGLEC-15
  • Links
    NCBI Gene ID: 284266
    neXtProt AC: NX_Q6ZMC9
    UniProt: Q6ZMC9

  • Chr Location
    18q12.3; chr18:45825675-45844094 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit impaired osteoclast differentiation and function and mild osteopetrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    20
  • cDNA Data
    5
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000091055 Ensembl Gene Model | MGI Sequence Detail 13782 C57BL/6J ±  kb
    transcript ENSMUST00000170760 Ensembl | MGI Sequence Detail 1156 Not Applicable  
    polypeptide ENSMUSP00000126901 Ensembl | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR013106 Immunoglobulin V-set domain
      IPR042836 Sialic acid-binding Ig-like lectin 15
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 23
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:193006 Ishida-Kitagawa N, et al., Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12). J Biol Chem. 2012 May 18;287(21):17493-502
    • Latest
      J:353768 Pillsbury CE, et al., Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia. Cancer Res Commun. 2023 Jul;3(7):1248-1259
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory